{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:25Z","timestamp":1790429605918,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Right ventricular systolic dysfunction (\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              ) is a known risk factor for adverse outcome in surgical aortic valve replacement. Transcatheter aortic valve replacement (\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              ), on the other hand, has been shown to be either beneficial or have no effect on right ventricular systolic function. However, the prognostic significance of\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              on\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              has not been clearly determined. We conducted a systematic review and meta\u2010analysis to define the impact of\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              on outcomes in terms of 1\u2010year mortality in patients with severe aortic stenosis undergoing\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              An extensive literature review was performed, with an aim to identify clinical studies that focused on the prognosis and short\u2010term mortality of patients with severe symptomatic aortic stenosis who underwent\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              . A total of 3166 patients from 8 selected studies were included.\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              , as assessed with tricuspid annular plane systolic excursion, fractional area change or ejection fraction, was found to be a predictor of adverse procedural outcome after\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              (hazard ratio, 1.31; 95% CI, 1.1\u20131.55;\n              <jats:italic>P<\/jats:italic>\n              =0.002). Overall, we found that\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              did affect post\u2010\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              prognosis in 1\u2010year mortality rate.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with severe, symptomatic aortic stenosis and concomitant severe\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              have a poor 1\u2010year post\u2010\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              prognosis when compared with patients without\n              <jats:styled-content style=\"fixed-case\">RVSD<\/jats:styled-content>\n              . Right ventricular dilation and severe tricuspid regurgitation were associated with increased 1\u2010year morality post\u2010\n              <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>\n              and should be considered as independent risk factors. Further evaluations of long\u2010term morbidity, mortality, as well as sustained improvement in functional class and symptoms need to be conducted to determine the long\u2010term effects.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014463","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T09:01:15Z","timestamp":1591779675000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Prognostic Assessment of Right Ventricular Systolic Dysfunction on Post\u2013Transcatheter Aortic Valve Replacement Short\u2010Term Outcomes: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"9","author":[{"given":"Salih N.","family":"Grevious","sequence":"first","affiliation":[{"name":"Cardiovascular Division Department of Medicine Boston University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ama K.","family":"Annor","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine Boston University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garly R.","family":"Saint Croix","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami Miller School of Medicine Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"de Marchena","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami Miller School of Medicine Miami FL"},{"name":"Cardiovascular Division Department of Medicine University of Miami Miller School of Medicine Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"G. Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami Miller School of Medicine Miami FL"},{"name":"Cardiovascular Division Department of Medicine University of Miami Miller School of Medicine Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine Boston University School of Medicine Boston MA"},{"name":"Cardiovascular Division Department of Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.08.030"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25512"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu290"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007477"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2018.0066"},{"key":"e_1_3_1_10_2","first-page":"304","article-title":"Impact of left ventricular filling parameters on outcome of patients undergoing trans\u2010catheter aortic valve replacement","volume":"18","author":"Kramer J","year":"2017","unstructured":"Kramer J, Biner S, Ghermezi M, Pressman GS, Shmueli H, Shimiaie J, Finkelstein A, Banai S, Steinvil A, Buffle E, et\u00a0al. Impact of left ventricular filling parameters on outcome of patients undergoing trans\u2010catheter aortic valve replacement. Eur Heart J Cardiovasc Imaging. 2017;18:304\u2013314.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312024"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12385"},{"key":"e_1_3_1_13_2","first-page":"603","article-title":"Left and right ventricular function in aortic stenosis patients 8\u00a0weeks post\u2010transcatheter aortic valve implantation or surgical aortic valve replacement","volume":"12","author":"Forsberg LM","year":"2011","unstructured":"Forsberg LM, Tamas E, Vanky F, Nielsen NE, Engvall J, Nylander E. Left and right ventricular function in aortic stenosis patients 8\u00a0weeks post\u2010transcatheter aortic valve implantation or surgical aortic valve replacement. Eur J Echocardiogr. 2011;12:603\u2013611.","journal-title":"Eur J Echocardiogr"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.08.016"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.085"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.09.018"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.117"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9880.1000447"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001546"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002073."},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003486"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.065"},{"key":"e_1_3_1_23_2","first-page":"142","article-title":"Prognostic impact of pre\u2010existing right ventricular dysfunction on the outcome of transcatheter aortic valve implantation","volume":"25","author":"Poliacikova P","year":"2013","unstructured":"Poliacikova P, Cockburn J, Pareek N, James R, Lee L, Trivedi U, de Belder A, Hildick\u2010Smith D. Prognostic impact of pre\u2010existing right ventricular dysfunction on the outcome of transcatheter aortic valve implantation. J Invasive Cardiol. 2013;25:142\u2013145.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130423"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.12.015"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.062"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007000"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818d8b92"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:31:24Z","timestamp":1715599884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,16]]}},"alternative-id":["10.1161\/JAHA.119.014463"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014463","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014463"}}