{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:32:59Z","timestamp":1790429579419,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,2,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Electrocardiographic strain pattern (ESP) has recently been associated with increased adverse outcome in aortic stenosis and after surgical aortic valve replacement. Our study sought to determine the impact and incremental value of ESP pattern in predicting adverse outcome after transcatheter aortic valve replacement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 585 patients with severe aortic stenosis (mean age, 83\u00b17\u00a0years; men, 39.8%) were enrolled for transcatheter aortic valve replacement from November 2012 to May 2018. ESP was defined as \u22651\u2010mm concave down\u2010sloping ST\u2010segment depression and asymmetrical T\u2010wave inversion in the lateral leads. The primary end points of the study were all\u2010cause mortality, rehospitalization for heart failure, myocardial infarction, and stroke. A total of 178 (30.4%) patients were excluded because of left bundle\u2010branch block (n=103) or right bundle\u2010branch block (n=75). Among the 407 remaining patients, 106 had ESP (26.04%). At a median follow\u2010up of 20.00\u00a0months (11.70\u201329.42 months), no impact of electric strain on overall and cardiac death could be established. By contrast, incidence of rehospitalization for heart failure was significantly higher (33\/106 [31.1%] versus 33\/301 [11%];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in patients with ESP. By multivariate analyses, ESP remained a strong predictor of rehospitalization for heart failure (hazard ratio, 2.75 [95% CI, 1.61\u20134.67];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with aortic stenosis who were eligible for transcatheter aortic valve replacement, ESP is frequent and associated with an increased risk of postinterventional heart failure regardless of preoperative left ventricular hypertrophy. ESP represents an easy, objective, reliable, and low\u2010cost tool to identify patients who may benefit from intensified postinterventional follow\u2010up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014481","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T10:06:35Z","timestamp":1610877995000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Electrocardiographic Strain Pattern Is a Major Determinant of Rehospitalization for Heart Failure After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"10","author":[{"given":"Jo\u00e9","family":"Heger","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico\u2010Chirurgicale Cardio\u2010Vasculaire Nouvel H\u00f4pital CivilCentre Hospitalier UniversitaireUniversit\u00e9 de Strasbourg Strasbourg 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