{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:30:48Z","timestamp":1790767848481,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"\n Background<\/jats:title>\n \n This study evaluated the impact of hepatitis C\u2013positive (\n HCV<\/jats:styled-content>\n +) donors on outcomes of heart transplantation in the United States.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Adults undergoing isolated heart transplantation in the United States between January 1, 2016, and December 31, 2018, were included. The primary outcome was 1\u2010year post\u2010transplant survival. Multivariable Cox regression and 2:1 propensity matching were used to compare outcomes between transplants with\n HCV<\/jats:styled-content>\n + and hepatitis C\u2013negative (\n HCV<\/jats:styled-content>\n \u2212) donors. A subanalysis was performed to evaluate the impact of nucleic acid amplification test positivity on outcomes. Of 7889 isolated heart transplants performed during the study period, 343 (4.4%) used\n HCV<\/jats:styled-content>\n + donors. Overall unadjusted 1\u2010year posttransplant survival was not statistically different between\n HCV<\/jats:styled-content>\n \u2212 versus\n HCV<\/jats:styled-content>\n + donors (91.1% versus 90.2%;\n P<\/jats:italic>\n =0.86), a finding that persisted after risk adjustment (hazard ratio, 1.05; 95% CI, 0.70\u20131.58;\n P<\/jats:italic>\n =0.80). Propensity matching resulted in 675 well\u2010balanced patients (437\n HCV<\/jats:styled-content>\n \u2212 and 238\n HCV<\/jats:styled-content>\n +). Overall 1\u2010year posttransplant survival was not statistically different in propensity\u2010matched analysis (89.8%\n HCV<\/jats:styled-content>\n \u2212 versus 89.2%\n HCV<\/jats:styled-content>\n +;\n P<\/jats:italic>\n =0.88). Rates of 1\u2010year drug\u2010treated rejection (21.1% versus 22.1%;\n P<\/jats:italic>\n =0.84), postoperative dialysis (11.4% versus 14.7%;\n P<\/jats:italic>\n =0.22), and stroke (4.6% versus 2.1%;\n P<\/jats:italic>\n =0.10) were also not statistically different between\n HCV<\/jats:styled-content>\n \u2212 and\n HCV<\/jats:styled-content>\n + groups, respectively. Outcomes were not statistically different between nucleic acid amplification test\u2013negative and nucleic acid amplification test\u2013positive\n HCV<\/jats:styled-content>\n + donors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Adult heart transplants using\n HCV<\/jats:styled-content>\n + donors, including those that are nucleic acid amplification test positive, can be performed without an adverse impact on 1\u2010year survival. Wider implementation of protocols for using\n HCV<\/jats:styled-content>\n + donors and an assessment of longer\u2010term outcomes including seroconversion rates will be important in maximizing the effect of\n HCV<\/jats:styled-content>\n + donors on national donor shortages.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014495","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T10:00:25Z","timestamp":1578477625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Outcomes of Adult Heart Transplantation Using Hepatitis C\u2013Positive Donors"],"prefix":"10.1161","volume":"9","author":[{"given":"Arman","family":"Kilic","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Hickey","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mathier","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Sultan","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gleason","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Horn","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Keebler","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13055"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1843"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812406"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.01.1293"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15311"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14381"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.03.076"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005276"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00148-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07339-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.703"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.066431"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.09.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00472-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199011000-00008"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:00:47Z","timestamp":1715601647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,21]]}},"alternative-id":["10.1161\/JAHA.119.014495"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014495","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"assertion":[{"value":"2019-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014495"}}