{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:38Z","timestamp":1790808218981,"version":"4.1.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The association of depressive symptoms with health status in peripheral artery disease (PAD) is understudied. No reports of differential impact on women have been described.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The PORTRAIT (Patient\u2010Centered Outcomes Related to Treatment Practices in Peripheral Artery Disease Investigating Trajectories) registry enrolled 1243 patients from vascular specialty clinics with new or worsening PAD symptoms. Depressive symptoms were assessed at baseline and 3\u00a0months using the 8\u2010Item Patient Health Questionnaire (score \u226510 indicating clinically relevant depressive symptoms). Disease\u2010specific and generic health status were measured by Peripheral Artery Questionnaire and EQ\u20105D Visual Analogue Scale at baseline and 3, 6, and 12\u00a0months. An adjusted general linear model for repeated measures was constructed for baseline and 3\u2010, 6\u2010, and 12\u2010month health status outcomes by depressive symptoms at baseline. Differences by sex were tested with interaction effects. The mean age was 67.6\u00b19.4\u00a0years with 38% (n=470) women. More women than men (21.1% versus 12.9%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) presented with severe depressive symptoms. In the adjusted model, patients with depressive symptoms had worse health status at each time point (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Results were similar for EQ\u20105D Visual Analogue Scale scores. The magnitude in 1\u2010year change in health status scores did not differ by sex. Depressive symptoms explained 19% of the association between sex differences in 1\u2010year Peripheral Artery Questionnaire summary scores.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Women with PAD have a high burden of depressive symptoms. Depressive symptoms were associated with a strikingly worse disease\u2010specific health status recovery path over the year following PAD diagnosis in men and women. Developing and testing interventions to address depressive symptoms in PAD are urgently needed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01419080.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014583","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T09:00:44Z","timestamp":1597222844000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences"],"prefix":"10.1161","volume":"9","author":[{"given":"Qurat\u2010ul\u2010ain","family":"Jelani","sequence":"first","affiliation":[{"name":"Vascular Medicine Outcomes Program Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mena\u2010Hurtado","sequence":"additional","affiliation":[{"name":"Vascular Medicine Outcomes Program Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Burg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale University School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Soufer","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine VA Connecticut Healthcare System West Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensey","family":"Gosch","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Jones","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2013Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2013Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basmah","family":"Safdar","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Vascular Medicine Outcomes Program Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2013.12.008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191259"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000102971.85504.7c"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13415"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X13493825"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.593442"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.11.1197"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.775247"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137913.26087.F0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm511oa"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2005.07.019"},{"key":"e_1_3_2_15_2","first-page":"157","article-title":"Peripheral vascular disease in a middle\u2010aged population sample: the Jerusalem Lipid Research Clinic Prevalence Study","volume":"23","author":"Gofin R","year":"1987","unstructured":"Gofin R, Kark JD, Friedlander Y, Lewis BS, Witt H, Stein Y, Gotsman MS. 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