{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:52:21Z","timestamp":1793040741539,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n \n This study assessed the prevalence of left ventricular (\n LV<\/jats:styled-content>\n ) involvement and characterized the clinical, electrocardiographic, and imaging features of\n LV<\/jats:styled-content>\n phenotype in patients with arrhythmogenic right ventricular cardiomyopathy (\n ARVC<\/jats:styled-content>\n ). Differential diagnosis between\n ARVC<\/jats:styled-content>\n \u2010\n LV<\/jats:styled-content>\n phenotype and dilated cardiomyopathy (\n DCM<\/jats:styled-content>\n ) was evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The study population included 87\n ARVC<\/jats:styled-content>\n patients (median age 34\u00a0years) and 153\n DCM<\/jats:styled-content>\n patients (median age 51\u00a0years). All underwent cardiac magnetic resonance with quantitative tissue characterization. Fifty\u2010eight\n ARVC<\/jats:styled-content>\n patients (67%) had\n LV<\/jats:styled-content>\n involvement, with both\n LV<\/jats:styled-content>\n systolic dysfunction and\n LV<\/jats:styled-content>\n late gadolinium enhancement (\n LGE<\/jats:styled-content>\n ) in 41\/58 (71%) and\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n in isolation in 17 (29%). Compared with\n DCM<\/jats:styled-content>\n , the\n ARVC<\/jats:styled-content>\n \u2010\n LV<\/jats:styled-content>\n phenotype was statistically significantly more often characterized by low\n QRS<\/jats:styled-content>\n voltages in limb leads, T\u2010wave inversion in the inferolateral leads and major ventricular arrhythmias.\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n was found in all\n ARVC<\/jats:styled-content>\n patients with\n LV<\/jats:styled-content>\n systolic dysfunction and in 69\/153 (45%) of\n DCM<\/jats:styled-content>\n patients. Patients with\n ARVC<\/jats:styled-content>\n and\n LV<\/jats:styled-content>\n systolic dysfunction had a greater amount of\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n (25% versus 13% of\n LV<\/jats:styled-content>\n mass;\n P<\/jats:italic>\n <0.01), mostly localized in the subepicardial\n LV<\/jats:styled-content>\n wall layers. An\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n \u226520% had a 100% specificity for diagnosis of\n ARVC<\/jats:styled-content>\n \u2010\n LV<\/jats:styled-content>\n phenotype. An inverse correlation between\n LV<\/jats:styled-content>\n ejection fraction and\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n extent was found in the\n ARVC<\/jats:styled-content>\n \u2010\n LV<\/jats:styled-content>\n phenotype (\n r<\/jats:italic>\n =\u22120.63;\n P<\/jats:italic>\n <0.01), but not in\n DCM<\/jats:styled-content>\n (\n r<\/jats:italic>\n =\u22120.01;\n P<\/jats:italic>\n =0.94).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LV<\/jats:styled-content>\n involvement in\n ARVC<\/jats:styled-content>\n is common and characterized by clinical and cardiac magnetic resonance features which differ from those seen in\n DCM<\/jats:styled-content>\n . The most distinctive feature of\n ARVC<\/jats:styled-content>\n \u2010\n LV<\/jats:styled-content>\n phenotype is the large amount of\n LV<\/jats:styled-content>\n \u2010\n LGE<\/jats:styled-content>\n \/fibrosis, which impacts directly and negatively on the\n LV<\/jats:styled-content>\n systolic function.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014628","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T10:00:19Z","timestamp":1583143219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":144,"title":["Arrhythmogenic Right Ventricular Cardiomyopathy: Characterization of Left Ventricular Phenotype and Differential Diagnosis With Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"9","author":[{"given":"Alberto","family":"Cipriani","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Thiene","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Iliceto","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua 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