{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:59Z","timestamp":1787018099400,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The inflammatory biomarker YKL\u201040 has previously been studied as a potential risk marker in cardiovascular disease. We aimed to assess the prognostic reclassification potential of serum YKL\u201040 in patients with stable coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The main study population was the placebo group of the CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) trial. The primary outcome was a composite of acute myocardial infarction, unstable angina pectoris, cerebrovascular disease, and all\u2010cause mortality. We used Cox proportional hazards regression models adjusted for C\u2010reactive protein level and baseline cardiovascular risk factors. Improvement in prediction by adding serum YKL\u201040 to the risk factors was calculated using the Cox\u2010Breslow method and c\u2010statistic. A total of 2200 patients were randomized to placebo, with a follow\u2010up duration of 10\u00a0years. YKL\u201040 was associated with an increased risk of the composite outcome (hazard ratio per unit increase in (YKL\u201040) 1.13, 95% CI 1.03\u20131.24,\n                      <jats:italic>P<\/jats:italic>\n                      =0.013) and all\u2010cause mortality (hazard ratio 1.32, 95% CI 1.17\u20131.49,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). Considering whether a composite\u2010outcome event was more likely to have, or not have, occurred to date, we found 68.4% of such predictions to be correct when based on the standard predictors, and 68.5% when serum YKL\u201040 was added as a predictor. Equivalent results were obtained with c\u2010statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Higher serum YKL\u201040 was independently associated with an increased risk of adverse cardiovascular outcomes and mortality. Addition of YKL\u201040 did not improve risk prediction in patients with stable coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/\">https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n                      . Unique identifier: NCT00121550.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.014634","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T05:00:19Z","timestamp":1583125219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Prognosis and Reclassification by YKL\u201040 in Stable Coronary Artery Disease"],"prefix":"10.1161","volume":"9","author":[{"given":"Jakob","family":"Schroder","sequence":"first","affiliation":[{"name":"Department of Cardiology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus Christian","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Cardiology Holb\u00e6k Hospital Holb\u00e6k Denmark"},{"name":"Department of Regional Health Research The Faculty of Heath Sciences University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Winkel","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Hilden","sequence":"additional","affiliation":[{"name":"Section\u00a0of Biostatistics Department of Public Health Research University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm Boje","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hvidovre Hospital Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Sajadieh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"\u00c4rnl\u00f6v","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society\/Division of Family Medicine Karolinska Institute Stockholm Sweden"},{"name":"Department of Health and Social Sciences Dalarna University Falun Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Harutyunyan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University of Copenhagen K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia S.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Medicine Herlev and Gentofte Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Kj\u00f8ller","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Cardiology S Herlev Hospital University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kastrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University of Copenhagen K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.683110"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca.15.39"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305233"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu203"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2018.02.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.687"},{"key":"e_1_3_2_9_2","first-page":"172","article-title":"Studies on serum YKL\u201040 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer","volume":"53","author":"Johansen JS","year":"2006","unstructured":"Johansen JS. 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