{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:13:10Z","timestamp":1793686390004,"version":"4.5.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Inflammation may contribute to incident heart failure (\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              ). Rheumatoid arthritis (\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              ), a prototypic inflammatory condition, may serve as a model for understanding inflammation\u2010related\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              risk.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the Vanderbilt University Medical Center electronic health record, we retrospectively identified 9889 patients with RA and 9889 control patients without autoimmune disease matched for age, sex, and race. Prevalent\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              at entry into the electronic health record or preceding\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              diagnosis was excluded. Incident\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              was ascertained using\n              <jats:italic>International Classification of Diseases, Ninth Revision (ICD\u20109),<\/jats:italic>\n              codes and medications. Over 177\u00a0566 person\u2010years of follow\u2010up, patients with\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              were at 21% greater risk of\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              (95% CI, 3\u201342%) independent of traditional cardiovascular risk factors. Among patients with\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              , higher CRP (C\u2010reactive protein) was associated with greater\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              risk (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), while the anti\u2010inflammatory drug methotrexate was associated with \u224825% lower\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              risk (\n              <jats:italic>P<\/jats:italic>\n              =0.021). In a second cohort (n=115) of prospectively enrolled patients with and without\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              , we performed proteomics and cardiac magnetic resonance imaging to discover circulating markers of inflammation associated with cardiac structure and function. Artemin levels were higher in patients with RA compared with controls (\n              <jats:italic>P<\/jats:italic>\n              =0.009), and higher artemin levels were associated with worse ventricular end\u2010systolic elastance and ventricular\u2010vascular coupling ratio (\n              <jats:italic>P<\/jats:italic>\n              =0.044 and\n              <jats:italic>P<\/jats:italic>\n              =0.031, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              , a prototypic chronic inflammatory condition, is associated with increased risk of\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              . Among patients with\n              <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n              , higher levels of CRP were associated with greater\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              risk, while methotrexate was associated with lower risk.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014661","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T09:06:04Z","timestamp":1588842364000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Heart Failure Risk Associated With Rheumatoid Arthritis\u2013Related Chronic Inflammation"],"prefix":"10.1161","volume":"9","author":[{"given":"Michael J.","family":"Ahlers","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville TN"},{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC) Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon D.","family":"Lowery","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC) Vanderbilt University Medical Center Nashville TN"},{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Farber\u2010Eger","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC) Vanderbilt University Medical Center Nashville TN"},{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC) Vanderbilt University Medical Center Nashville TN"},{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bradham","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Ormseth","sequence":"additional","affiliation":[{"name":"Divisions of Rheumatology and Clinical Pharmacology Vanderbilt University Medical Center Nashville TN"},{"name":"Tennessee Valley Healthcare System U.S. Department of Veterans Affairs Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia P.","family":"Chung","sequence":"additional","affiliation":[{"name":"Divisions of Rheumatology and Clinical Pharmacology Vanderbilt University Medical Center Nashville TN"},{"name":"Tennessee Valley Healthcare System U.S. Department of Veterans Affairs Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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