{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:02:12Z","timestamp":1781816532635,"version":"3.54.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"\n Background<\/jats:title>\n \n Left atrial (\n LA<\/jats:styled-content>\n ) size and cardiorespiratory fitness (\n CRF<\/jats:styled-content>\n ) are predictors of future cardiovascular events in high\u2010risk populations.\n LA<\/jats:styled-content>\n dilatation is a diagnostic criterion for left ventricular diastolic dysfunction. However,\n LA<\/jats:styled-content>\n is dilated in endurance athletes with high\n CRF<\/jats:styled-content>\n , but little is known about the association between\n CRF<\/jats:styled-content>\n and\n LA<\/jats:styled-content>\n size in healthy, free\u2010living individuals. We hypothesized that in a healthy population,\n LA<\/jats:styled-content>\n size was associated with\n CRF<\/jats:styled-content>\n and leisure\u2010time physical activity, but not with echocardiographic indexes of left ventricular diastolic dysfunction.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In this cross\u2010sectional study from HUNT (Nord\u2010Tr\u00f8ndelag Health Study), 107 men and 138 women, aged 20 to 82\u00a0years, without hypertension, cardiovascular, pulmonary, or malignant disease participated.\n LA<\/jats:styled-content>\n volume was assessed by echocardiography and indexed to body surface area LAVI (left atrial volume index).\n CRF<\/jats:styled-content>\n was measured as peak oxygen uptake (\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n ) using ergospirometry, and percent of age\u2010 and\u2010sex\u2010predicted\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n was calculated. Indexes of left ventricular diastolic dysfunction were assessed in accordance with latest recommendations.\n LAVI<\/jats:styled-content>\n was >34\u00a0mL\/m\n 2<\/jats:sup>\n in 39% of participants, and\n LAVI<\/jats:styled-content>\n was positively associated with\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n and percentage of age\u2010 and\u2010sex\u2010predicted\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n (\u03b2 (95% CI) 0.18 (0.09\u20100.28) and 0.10 (0.05\u20100.15)), respectively) weighted minutes of physical activity per week (\u03b2 [95%\n CI<\/jats:styled-content>\n ], 0.01 [0.003\u20130.015]).\n LAVI<\/jats:styled-content>\n was not associated with other indexes of left ventricular diastolic dysfunction. There was an effect modification between age and\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n \/percentage of age\u2010 and\u2010sex\u2010predicted\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n showing higher\n LAVI<\/jats:styled-content>\n with advanced age and higher\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n \/percentage of age\u2010 and\u2010sex\u2010predicted\n VO<\/jats:styled-content>\n 2peak<\/jats:sub>\n as presented in prediction diagrams.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Interpretation of\n LAVI<\/jats:styled-content>\n as a marker of diastolic dysfunction should be done in relation to age\u2010relative\n CRF<\/jats:styled-content>\n . Studies on the prognostic value of\n LAVI<\/jats:styled-content>\n in fit subpopulations are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014682","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T10:00:19Z","timestamp":1580205619000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Left Atrial Volume, Cardiorespiratory Fitness, and Diastolic Function in Healthy Individuals: The HUNT Study, Norway"],"prefix":"10.1161","volume":"9","author":[{"given":"Jon Magne","family":"Letnes","sequence":"first","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"},{"name":"Clinic of Cardiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne","family":"Nes","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"},{"name":"Clinic of Cardiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Vaardal\u2010Lunde","sequence":"additional","affiliation":[{"name":"University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine Bratt","family":"Slette","sequence":"additional","affiliation":[{"name":"Innlandet Hospital Lillehammer Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald Edvard","family":"M\u00f8lmen\u2010Hansen","sequence":"additional","affiliation":[{"name":"Asgardstrand General Practice Horten Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stian Thoresen","family":"Aspenes","sequence":"additional","affiliation":[{"name":"Department of Health Registries Norwegian Directorate of Health Oslo Norway"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn","family":"St\u00f8ylen","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"},{"name":"Clinic of Cardiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Dalen","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway"},{"name":"Clinic of Cardiology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"},{"name":"Department of Medicine Levanger Hospital Nord\u2010Tr\u00f8ndelag Hospital Trust Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066318.21784.43"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.1622"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.077"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02864-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.12.032"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.052"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002487"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.03.036"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.01.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys095"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep188"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-63"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064319"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000219"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer137"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005598"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037615"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-19"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.054"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.12.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.091"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2014.985657"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-018-1427-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.07.015"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.034"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12150"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S103346"}],"updated-by":[{"DOI":"10.1161\/jaha.119.014627","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000}}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:39:11Z","timestamp":1715600351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,4]]}},"alternative-id":["10.1161\/JAHA.119.014682"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014682","relation":{"correction":[{"id-type":"doi","id":"10.1161\/JAHA.119.014627","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]},"assertion":[{"value":"2019-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014682"}}