{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:00Z","timestamp":1787018100374,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The relationship between orthostatic hypotension and clinical outcome in older adults is poorly understood. Blood pressure drop rate (ie, speed of blood pressure drop) may particularly reflect the imposed challenge to the baroreflex and the associated clinical outcome (ie, frailty and number of falls). This study aimed to compare orthostatic blood pressure drop rate and drop magnitude with regard to their association with frailty and number of falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Blood pressure was measured continuously during a standardized active stand task in 168 patients (mean age 81.4\u00b17.0; 55.4% female) who visited a geriatric outpatient clinic for cognitive or mobility problems. The association of orthostatic blood pressure drop rate, blood pressure drop magnitude, and baroreflex sensitivity (ie, increase in heart rate divided by systolic blood pressure drop magnitude) with frailty (Fried criteria and 4 frailty markers) and self\u2010reported number of falls was assessed using linear regression models, adjusting for age and sex. Systolic blood pressure drop rate had the strongest association with frailty according to the 4 frailty markers (\u03b2 0.30; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.11\u20130.49;\n                      <jats:italic>P<\/jats:italic>\n                      =0.003) and number of falls (\u03b2 1.09; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.19\u20131.20;\n                      <jats:italic>P<\/jats:italic>\n                      =0.018); diastolic blood pressure drop magnitude was most strongly associated with frailty according to the Fried criteria (\u03b2 0.37; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.15\u20130.60;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Baroreflex sensitivity was associated with neither frailty nor number of falls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Orthostatic blood pressure drop rate was associated with frailty and falls and may reflect the challenge to the baroreflex rather than drop magnitude.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.014688","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T05:00:30Z","timestamp":1585544430000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Blood Pressure Drop Rate After Standing Up Is Associated With Frailty and Number of Falls in Geriatric Outpatients"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-7663","authenticated-orcid":false,"given":"Arjen","family":"Mol","sequence":"first","affiliation":[{"name":"Department of Human Movement Sciences @AgeAmsterdam Amsterdam Movement Sciences Vrije Universiteit Amsterdam the Netherlands"},{"name":"Department of Biophysics Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-0474","authenticated-orcid":false,"given":"Lois Robin Nicolle","family":"Slangen","sequence":"additional","affiliation":[{"name":"Department of Biophysics Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-1206","authenticated-orcid":false,"given":"Marijke C.","family":"Trappenburg","sequence":"additional","affiliation":[{"name":"Section of Gerontology and Geriatrics Department of Internal Medicine VU University Medical Center Amsterdam Amsterdam the Netherlands"},{"name":"Department of Internal Medicine Amstelland Hospital Amstelveen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4197-4800","authenticated-orcid":false,"given":"Esmee M.","family":"Reijnierse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aged Care @AgeMelbourne The Royal Melbourne Hospital The University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-7069","authenticated-orcid":false,"given":"Richard J. A.","family":"van Wezel","sequence":"additional","affiliation":[{"name":"Department of Biophysics Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen the Netherlands"},{"name":"Biomedical Signals and Systems MIRA Institute for Biomedical Technology and Technical Medicine University of Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-5611","authenticated-orcid":false,"given":"Carel G. M.","family":"Meskers","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences @AgeAmsterdam Amsterdam Movement Sciences Vrije Universiteit Amsterdam the Netherlands"},{"name":"Department of Rehabilitation Medicine VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-1724","authenticated-orcid":false,"given":"Andrea B.","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences @AgeAmsterdam Amsterdam Movement Sciences Vrije Universiteit Amsterdam the Netherlands"},{"name":"Department of Medicine and Aged Care @AgeMelbourne The Royal Melbourne Hospital The University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.10.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.02.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.079"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010060"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls214"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106808"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00694"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00848.2012"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01186.2007"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000872"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03352.x"},{"key":"e_1_3_2_15_2","first-page":"272","article-title":"What is the relationship between frailty and orthostatic hypotension in older adults?","volume":"3","author":"Kocyigit SE","year":"2019","unstructured":"Kocyigit SE, Soysal P, Bulut EA, Aydin AE, Dokuzlar O, Isik AT. What is the relationship between frailty and orthostatic hypotension in older adults? J Geriatr Cardiol. 2019;3:272\u2013279.","journal-title":"J Geriatr Cardiol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13656"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/31.3.181"},{"key":"e_1_3_2_18_2","first-page":"439","article-title":"A prospective study of the association between orthostatic hypotension and falls: definition matters","volume":"46","author":"McDonald C","year":"2016","unstructured":"McDonald C, Pearce M, Kerr SR, Newton J. A prospective study of the association between orthostatic hypotension and falls: definition matters. Age Ageing. 2016;46:439\u2013445.","journal-title":"Age Ageing"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005521"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/30.4.289"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0327-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3280b083bd"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.9.1157"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.11.003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04402-X"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.01.013"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqu024"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0295-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4875231"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833951ef"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:27:16Z","timestamp":1715585236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,9]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,4,9]]}},"alternative-id":["10.1161\/JAHA.119.014688"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014688","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,9]]},"assertion":[{"value":"2020-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014688"}}