{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:14Z","timestamp":1790716874475,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data regarding the phenotypic correlates and prognostic value of albumin in heart failure with preserved ejection fraction (HFpEF) are scarce. The goal of the current study is to determine phenotypic correlates (myocardial hypertrophy, myocardial fibrosis, detailed pulsatile hemodynamics, and skeletal muscle mass) and prognostic implications of serum albumin in HFpEF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 118 adults with HFpEF. All\u2010cause death or heart\u2010failure\u2013related hospitalization was ascertained over a median follow\u2010up of 57.6\u00a0months. We measured left ventricular mass, myocardial extracellular volume, and axial muscle areas using magnetic resonance imaging. Pulsatile arterial hemodynamics were assessed with a combination of arterial tonometry and phase\u2010contrast magnetic resonance imaging. Subjects with lower serum albumin exhibited a higher body mass index, and a greater proportion of black ethnicity and diabetes mellitus. A low serum albumin was associated with higher myocardial extracellular volume (52.3 versus 57.4 versus 39.3\u00a0mL in lowest to highest albumin tertile, respectively;\n              <jats:italic>P<\/jats:italic>\n              =0.0023) and greater N\u2010terminal pro B\u2010type natriuretic peptide levels, but not with a higher myocardial cellular volume (123 versus 114 versus 102\u00a0mL;\n              <jats:italic>P<\/jats:italic>\n              =0.13). Lower serum albumin was also associated with an increased forward wave amplitude and markedly increased pulsatile power in the aorta. Serum albumin was a strong predictor of death or heart failure hospitalization even after adjustment for N\u2010terminal pro B\u2010type natriuretic peptide levels and the Meta\u2010Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score (adjusted standardized hazard ratio=0.56; 95% CI=0.37\u20130.83;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Serum albumin is associated with myocardial fibrosis, adverse pulsatile aortic hemodynamics, and prognosis in HFpEF. This readily available clinical biomarker can enhance risk stratification in HFpEF and identifies a subgroup with specific pathophysiological abnormalities.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014716","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:12:30Z","timestamp":1580728350000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Serum Albumin Is a Marker of Myocardial Fibrosis, Adverse Pulsatile Aortic Hemodynamics, and Prognosis in Heart Failure With Preserved Ejection Fraction"],"prefix":"10.1161","volume":"9","author":[{"given":"Stuart B.","family":"Prenner","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"},{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Pillutla","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowjanya","family":"Yenigalla","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh, Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Gaddam","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"},{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armghan Haider","family":"Ans","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Jehangir","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"},{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payman","family":"Zamani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Akers","sequence":"additional","affiliation":[{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio A.","family":"Chirinos","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA"},{"name":"Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA"},{"name":"Departments of Internal Medicine and Radiology Corporal Michael J. 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