{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:49:21Z","timestamp":1790041761637,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular disease remains a leading cause of death among women. Despite improvements in the management of patients with acute coronary syndrome (\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              ), women with an\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              remain at higher risk.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a time\u2010dependent analysis of the management and outcomes of women admitted with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              who enrolled in the prospective biennial\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              Israeli Surveys between 2000 and 2016. Surveys were divided into 3 time periods (2000\u20102004, 2006\u20102010, and 2013\u20102016). Outcomes included 30\u2010day major adverse cardiac events (death, myocardial infarction, stroke, unstable angina, stent thrombosis, urgent revascularization) and 1\u2010year mortality. Overall, 3518 women were admitted with an\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              . Their mean age (70\u00b112\u00a0years) was similar among the time periods. Over the time course of the study, more women were admitted with non\u2013\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010elevation\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              (51.9%, 59.6%, and 66.1%, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and statins and percutaneous coronary intervention were increasingly utilized (66%, 91%, 93%, and 42%, 60%, and 68%, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for each). Among women with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment\u2013elevation myocardial infarction, more primary percutaneous coronary interventions were performed (48.5%, 84.7%, and 95.3%, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The rate of 30\u2010day major adverse cardiac events has significantly decreased over the years (24.6%, 18.6%, and 13.5%, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). However, 1\u2010year mortality rates declined only from 2000 to 2004 (16.9%, 12.8%, and 12.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.007 for the overall difference), and this change was not significant after propensity matching or multivariate analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Over more than a decade, 30\u2010day major adverse cardiac events have decreased among women with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              . Advances in pharmacological treatments and an early invasive approach may have accounted for this improvement. However, the lack of further reduction in 1\u2010year mortality rates among women suggests that more measures should be provided in this high\u2010risk population.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014721","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T10:00:29Z","timestamp":1576749629000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Temporal Trends Analysis of the Characteristics, Management, and Outcomes of Women With Acute Coronary Syndrome (ACS): ACS Israeli Survey Registry 2000\u20102016"],"prefix":"10.1161","volume":"9","author":[{"given":"Avital","family":"Porter","sequence":"first","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center Sheba Medical Center Tel Hashomer Israel"},{"name":"Israeli Association for Cardiovascular Trials Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Eisen","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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Life expectancy in Israel 2016. Available at: https:\/\/www.cbs.gov.il\/he\/mediarelease\/DocLib\/2017\/362\/05_17_362b.pdf. Accessed November 15 2019."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:57:09Z","timestamp":1715597829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.014721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,7]]}},"alternative-id":["10.1161\/JAHA.119.014721"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.014721","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"2019-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e014721"}}