{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:01Z","timestamp":1786985041978,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The impact of hyperoxia, that is, supraphysiological arterial partial pressure of O\n              <jats:sub>2<\/jats:sub>\n              , on myocardial oxygen balance and function in stable multivessel coronary artery disease (\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              ) is poorly understood. In this observational study, we assessed myocardial effects of inhalational hyperoxia in patients with\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              using a comprehensive cardiovascular magnetic resonance exam.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Twenty\u2010five patients with stable\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              underwent a contrast\u2010free cardiovascular magnetic resonance exam in the interval between their index coronary angiography and subsequent revascularization. The cardiovascular magnetic resonance exam involved T1 and T2 mapping for tissue characterization (fibrosis, edema) as well as function imaging, from which strain analysis was derived, and oxygenation\u2010sensitive cardiovascular magnetic resonance imaging. The latter modalities were both acquired at room air and after breathing pure O\n              <jats:sub>2<\/jats:sub>\n              by face mask at 10\u00a0L\/min for 5\u00a0minutes. In 14 of the 25\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              patients (56%), hyperoxia induced poststenotic myocardial deoxygenation with a subsequent oxygenation discordance across the myocardium. Extent of deoxygenation was correlated to degree of stenosis (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.434,\n              <jats:italic>P<\/jats:italic>\n              =0.033). Hyperoxia\u2010associated poststenotic deoxygenation was accompanied by ipsiregional reduction of diastolic strain rate (1.39\u00b10.57 versus 1.18\u00b10.65;\n              <jats:italic>P<\/jats:italic>\n              =0.045) and systolic radial velocity (37.40\u00b117.22 versus 32.88\u00b113.58;\n              <jats:italic>P<\/jats:italic>\n              =0.038). Increased T2, as well as lower cardiac index, and defined abnormal strain parameters on room air were predictive for hyperoxia\u2010induced abnormalities (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Furthermore, in patients with prolonged native T1 (&gt;1220\u00a0ms), hyperoxia reduced ejection fraction and peak strain.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              and pre\u2010existent myocardial injury who respond to hyperoxic challenge with strain abnormalities appear susceptible for hyperoxia\u2010induced regional deoxygenation and deterioration of myocardial function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02233634.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014739","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T10:00:25Z","timestamp":1582365625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Hyperoxia on Myocardial Oxygenation and Function in Patients With Stable Multivessel Coronary Artery Disease"],"prefix":"10.1161","volume":"9","author":[{"given":"Dominik P.","family":"Guensch","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Inselspital Bern University Hospital University of Bern Switzerland"},{"name":"Department of Diagnostic, Interventional and Paediatric Radiology Inselspital Bern University Hospital University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kady","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Inselspital Bern University Hospital University of Bern Switzerland"},{"name":"Department of Diagnostic, Interventional and Paediatric Radiology Inselspital Bern University Hospital University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inselspital University Hospital Bern University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Luescher","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Inselspital Bern University Hospital University of Bern 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