{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:49:42Z","timestamp":1758271782102,"version":"3.41.2"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In survivors of acute\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment\u2013elevation myocardial infarction (\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              ), increased aortic stiffness is associated with worse clinical outcome; however, the underlying pathomechanisms are incompletely understood. We aimed to investigate associations between aortic stiffness and infarct healing using comprehensive cardiac magnetic resonance imaging in patients with acute\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a prospective observational study including 103 consecutive\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients treated with primary percutaneous coronary intervention. Pulse wave velocity (\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              ), the reference standard for aortic stiffness assessment, was determined by a validated phase\u2010contrast cardiac magnetic resonance imaging protocol within the first week after\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              . Infarct healing, defined as relative infarct size reduction from baseline to 4\u00a0months post\u2010\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              , was determined using late gadolinium\u2010enhanced cardiac magnetic resonance. Median infarct size significantly decreased from 17% of left ventricular mass (interquartile range 9% to 28%) at baseline to 12% (6% to 17%) at 4\u2010month follow\u2010up (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Relative infarct size reduction was 36% (interquartile range 15% to 52%). Patients with a reduction &gt;36% were younger (\n              <jats:italic>P<\/jats:italic>\n              =0.01) and had lower baseline NT\u2010proBNP (N\u2010terminal pro\u2013B\u2010type natriuretic peptide) concentrations (\n              <jats:italic>P<\/jats:italic>\n              =0.047) and aortic\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              values (\n              <jats:italic>P<\/jats:italic>\n              =0.003). In a continuous (odds ratio 0.64 [95% CI, 0.49\u20130.84];\n              <jats:italic>P<\/jats:italic>\n              =0.001) as well as categorical (\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              &lt;7\u00a0m\/s; odds ratio 4.80 [95% CI, 1.89\u201312.20];\n              <jats:italic>P<\/jats:italic>\n              =0.001) multivariable logistic regression model, the relation between aortic\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              and relative infarct size reduction remained significant after adjustment for baseline infarct size, age, NT\u2010proBNP, and C\u2010reactive protein.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Aortic\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              independently predicted infarct size reduction as assessed by cardiac magnetic resonance, revealing a novel pathophysiological link between aortic stiffness and adverse infarct healing during the early phase after\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              treated with contemporary primary percutaneous coronary intervention.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014740","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T10:08:31Z","timestamp":1580465311000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Aortic Stiffness and Infarct Healing in Survivors of Acute ST\u2010Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"9","author":[{"given":"Martin","family":"Reindl","sequence":"first","affiliation":[{"name":"University Clinic of Internal Medicine III Cardiology and Angiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Tiller","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III Cardiology and Angiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Holzknecht","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III Cardiology and Angiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Lechner","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III Cardiology and Angiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Hein","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III Cardiology and Angiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Pamminger","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Henninger","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Mayr","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology Medical University of Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Josef","family":"Feistritzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at University of Leipzig 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