{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:15:12Z","timestamp":1780546512118,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"\n Background<\/jats:title>\n \n Sex difference in fractional flow reserve (\n FFR<\/jats:styled-content>\n ) and resting index has not been fully clarified. We sought to investigate the impact of sex on the discordance of revascularization decision making between\n FFR<\/jats:styled-content>\n and diastolic pressure ratio during the diastolic wave\u2010free period (\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 759 angiographically intermediate lesions with 30% to 80% diameter stenosis by quantitative coronary angiography in 577 patients in whom\n FFR<\/jats:styled-content>\n and\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n were measured were investigated.\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n was measured during the wave\u2010free window of 5 heart cycles at an independent core laboratory.\n FFR<\/jats:styled-content>\n \u22640.80 and\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n \u22640.89 were considered positive studies. A total of 164 vessels in 126 women (21.6%) and 595 vessels in 451 men (78.4%) were included. In lesions with negative\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n , positive\n FFR<\/jats:styled-content>\n was less frequently observed in women (13 of 73; 17.8%) than in men (97 of 286; 33.9%) (\n P<\/jats:italic>\n =0.009). In lesions with positive\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n , the frequency of negative\n FFR<\/jats:styled-content>\n was observed in 22 of 91 vessels (24.2%) in women and 51 of 309 vessels (16.5%) in men, which did not reach statistical significance (\n P<\/jats:italic>\n =0.098). In multivariable analyses, female sex was independently associated with\n FFR<\/jats:styled-content>\n \u2010\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n discordance both in negative\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n cohort (odds ratio, 0.44; 95%\n CI<\/jats:styled-content>\n , 0.21\u20130.98;\n P<\/jats:italic>\n =0.036) and in positive\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n cohort (odds ratio, 2.41; 95%\n CI<\/jats:styled-content>\n , 1.17\u20134.96;\n P<\/jats:italic>\n =0.017) after adjustment for age, weight, quantitative coronary angiography data, and baseline physiological indexes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The frequency of\n FFR<\/jats:styled-content>\n \u2010\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n discordance was significantly associated with sex, which may indicate potential shift of optimal threshold of either\n FFR<\/jats:styled-content>\n or\n \n dPR\n WFP<\/jats:sub>\n <\/jats:styled-content>\n , or both of them, according to sex.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014790","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T10:00:18Z","timestamp":1582797618000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Sex Difference on the Discordance of Revascularization Decision Making Between Fractional Flow Reserve and Diastolic Pressure Ratio During the Wave\u2010Free Period"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5008","authenticated-orcid":false,"given":"Taishi","family":"Yonetsu","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Sumino","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Niida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Umemoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsuchiura Kyodo General Hospital Ibaraki 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