{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:11:10Z","timestamp":1791231070156,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"\n Background<\/jats:title>\n \n Coronary artery disease risk factors are associated with atrial fibrillation (\n AF<\/jats:styled-content>\n ) and coronary endothelial dysfunction (\n CED<\/jats:styled-content>\n ). We hypothesized that\n CED<\/jats:styled-content>\n is associated with increased risk of incident\n AF<\/jats:styled-content>\n among patients with chest pain and nonobstructive coronary artery disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Three hundred patients with chest pain, nonobstructive coronary artery disease, and no history of\n AF<\/jats:styled-content>\n underwent intracoronary acetylcholine infusion for evaluation of baseline epicardial (decrease in mid\u2013left anterior descending coronary artery diameter in response to acetylcholine) and microvascular (<50% increase in coronary blood flow in response to acetylcholine)\n CED<\/jats:styled-content>\n . Primary outcome was incident\n AF<\/jats:styled-content>\n over a mean follow\u2010up period of 10.5\u00b15.5\u00a0years. Mean age was 53.3\u00b110.8\u00a0years, and 70% were women. Baseline clinical and echocardiographic characteristics were similar between patients with\n CED<\/jats:styled-content>\n (n=256) and those with normal endothelial function (n=44). Overall, 35 of 300 (12%) patients developed\n AF<\/jats:styled-content>\n , among whom 34 of 35 (97%) had\n CED<\/jats:styled-content>\n at baseline. Compared with normal endothelial function, the presence of\n CED<\/jats:styled-content>\n was associated with 11% increased absolute risk and 5.8\u2010fold increased relative risk of incident\n AF<\/jats:styled-content>\n . Moreover,\n CED<\/jats:styled-content>\n (\n odds ratio<\/jats:styled-content>\n , 3.87; 95%\n CI<\/jats:styled-content>\n , 1.27\u201347.0) and increased (>34\u00a0mL\/m\n 2<\/jats:sup>\n ) left atrial volume index (odds ratio, 3.87; 95%\n CI<\/jats:styled-content>\n , 1.60\u20139.11) were independent predictors of incident\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with normal coronary endothelial function, as compared with those with\n CED<\/jats:styled-content>\n and similar\n AF<\/jats:styled-content>\n risk factors, have significantly lower incidence of\n AF<\/jats:styled-content>\n on long\u2010term follow\u2010up. The potential mechanistic link between vascular dysfunction and\n AF<\/jats:styled-content>\n development warrants further investigation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.014850","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T09:02:08Z","timestamp":1587027728000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Coronary Endothelial Dysfunction Is Associated With Increased Risk of Incident Atrial Fibrillation"],"prefix":"10.1161","volume":"9","author":[{"given":"Michel T.","family":"Corban","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Godo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Burczak","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Department of Medicine Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Noseworthy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Toya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics and Informatics Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"},{"name":"Division of Nephrology and Hypertension Department of Medicine Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-5313","authenticated-orcid":false,"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester 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