{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:05:02Z","timestamp":1782284702350,"version":"3.54.5"},"reference-count":76,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Oxidative stress and high salt intake could be independent or intertwined risk factors in the origin of hypertension. Kidneys are the major organ to regulate sodium homeostasis and blood pressure and the renal dopamine system plays a pivotal role in sodium regulation during sodium replete conditions. Oxidative stress has been implicated in renal dopamine dysfunction and development of hypertension, especially in salt\u2010sensitive animal models. Here we show the nexus between high salt intake and oxidative stress causing renal tubular dopamine oxidation, which leads to mitochondrial and lysosomal dysfunction and subsequently causes renal inflammation and hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Male Sprague Dawley rats were divided into the following groups, vehicle (V)\u2014tap water, high salt (\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              )\u20141% NaCl, L\u2010buthionine\u2010sulfoximine (\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              ), a prooxidant, and\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              plus\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              without and with antioxidant resveratrol (R) for 6\u00a0weeks. Oxidative stress was significantly higher in\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              and\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              +\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              \u2013treated rat compared with vehicle; however, blood pressure was markedly higher in the\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              +\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              group whereas an increase in blood pressure in the\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              group was modest.\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              +\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              \u2013treated rats had significant renal dopamine oxidation, lysosomal and mitochondrial dysfunction, and increased renal inflammation; however,\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              alone had no impact on organelle function or inflammation. Resveratrol prevented oxidative stress, dopamine oxidation, organelle dysfunction, inflammation, and hypertension in\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              and\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              +\n              <jats:styled-content style=\"fixed-case\">BSO<\/jats:styled-content>\n              rats.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These data suggest that dopamine oxidation, especially during increased sodium intake and oxidative milieu, leads to lysosomal and mitochondrial dysfunction and renal inflammation with subsequent increase in blood pressure. Resveratrol, while preventing oxidative stress, protects renal function and mitigates hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.014977","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T22:00:22Z","timestamp":1577484022000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Renal Dopamine Oxidation and Inflammation in High Salt Fed Rats"],"prefix":"10.1161","volume":"9","author":[{"given":"Anees A.","family":"Banday","sequence":"first","affiliation":[{"name":"Heart and Kidney Institute College of Pharmacy University of Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa F.","family":"Lokhandwala","sequence":"additional","affiliation":[{"name":"Heart and Kidney Institute College of Pharmacy University of Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00594.2017"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13465"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021317-121134"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.02.034"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000373"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.07.006"},{"key":"e_1_3_1_8_2","first-page":"405","article-title":"Dopamine: not just a neurotransmitter","volume":"59","author":"Drozak J","year":"2005","unstructured":"Drozak J, Bryla J. 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