{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:41:35Z","timestamp":1789202495652,"version":"build-2803163510"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      It is unclear how recurrent pregnancy loss (\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      ) impacts disease risk and whether there is a difference in risk between women with or without a live birth before\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      (primary versus secondary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      ). We investigated the disease risk following\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      , and whether there was a difference between primary and secondary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Using population\u2010wide healthcare registries from Denmark, we identified a cohort of 1\u00a0370\u00a0896 ever\u2010pregnant women aged 12 to 40\u00a0years between 1977 and 2016. Of this cohort, 10\u00a0691 (0.77%) fulfilled the criteria for\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      (50.0% primary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      ). Average follow\u2010up was 15.8\u00a0years. Incidence rate ratios were calculated in a phenome\u2010wide manner. Diagnoses related to assessment and diagnosis of\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      and those appearing later in life were separated using a mixture model. Primary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      increased the risk of subsequent cardiovascular disorders, including atherosclerosis, cerebral infarction, heart failure, and pulmonary embolism, as well as systemic lupus erythematosus, chronic obstructive pulmonary disease, anxiety, and obsessive\u2010compulsive disorder. Women with secondary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      had no increased risk of cardiovascular disorders. However, we observed an increased risk of gastrointestinal disorders such as irritable bowel syndrome and intestinal malabsorption, as well as mental disorders and obstetric complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      is a risk factor for a spectrum of disorders, which is different for primary and secondary\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      . Screening following\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      explains some associations, but the remaining findings suggest that\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      influences or shares cause with cardiovascular disorders, autoimmune disorders, and mental disorders. Research into the pathophysiology of\n                      <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\n                      and later diseases merits further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.015069","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T05:02:27Z","timestamp":1587099747000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Phenome\u2010Wide Analysis of Short\u2010 and Long\u2010Run Disease Incidence Following Recurrent Pregnancy Loss Using Data From a 39\u2010Year Period"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-8432","authenticated-orcid":false,"given":"David","family":"Westergaard","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences 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