{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:49:01Z","timestamp":1780634941201,"version":"3.54.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small\u2010vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This population\u2010based study included 530 participants (age \u226560\u00a0years) who were free from dementia and functional dependence, derived from the Swedish National study on Aging and Care in Kungsholmen (2001\u20132003). We collected data on demographics, vascular risk factors, and health conditions through interviews, clinical examinations, laboratory tests, and patient registers. Cerebral PVSs and white matter hyperintensities on magnetic resonance images were visually assessed with semiquantitative visual rating scales. Data were analyzed using the general linear regression models. After controlling for demographics and cardiovascular disease, very high blood pressure (\u2265160\/100\u00a0mm\u00a0Hg) was significantly associated with global PVS score (\u03b2\u2010coefficient, 1.30; 95% CI, 0.06\u20132.53) and orthostatic hypotension was associated with PVS score in the basal ganglia (\u03b2\u2010coefficient 0.37; 0.03\u20130.70), but the associations became non\u2010significant when adjusting for white matter hyperintensity load. Orthostatic hypotension was significantly associated with global and lobar PVS scores in carriers but not in noncarriers of the\n              <jats:italic>APOE<\/jats:italic>\n              \u03b54 allele. Global or regional PVS score was not significantly associated with other traditional vascular risk factors such as smoking, diabetes mellitus, physical inactivity, and overweight or obesity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study provides limited evidence supporting a correlation of magnetic resonance imaging\u2013visible PVS with traditional vascular risk factors in older adults. The association of orthostatic hypotension with lobar PVS among\n              <jats:italic>APOE<\/jats:italic>\n              \u03b54 carriers suggests that lobar PVS may be a marker for amyloid\u2010associated small\u2010vessel disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015229","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T08:54:10Z","timestamp":1596531250000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Associations of Vascular Risk Factors and\n            <i>APOE<\/i>\n            Genotype With Perivascular Spaces Among Community\u2010Dwelling Older Adults"],"prefix":"10.1161","volume":"9","author":[{"given":"Anna","family":"Laveskog","sequence":"first","affiliation":[{"name":"Division of Neuro Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Department of Neuroradiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS) Aging Research Center Karolinska Institutet\u2010Stockholm University Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide L.","family":"Vetrano","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS) Aging Research Center Karolinska Institutet\u2010Stockholm University Stockholm Sweden"},{"name":"Centro di Medicina dell\u2019Invecchiamento IRCCS Fondazione Policlinico \u201cA. Gemelli\u201d Catholic University of Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Bronge","sequence":"additional","affiliation":[{"name":"Division of Neuro Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Olof","family":"Wahlund","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics NVS Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-4912","authenticated-orcid":false,"given":"Chengxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS) Aging Research Center Karolinska Institutet\u2010Stockholm University Stockholm 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