{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:44:42Z","timestamp":1787856282209,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiac remodeling predisposes individuals to heart failure if the burden is not solved, and heart failure is a growing cause of morbidity and mortality worldwide. The cardiac extracellular matrix not only provides structural support, but also is a core aspect of the myocardial response to various biomechanical stresses and heart failure. MFAP4 (microfibrillar\u2010associated protein 4) is an integrin ligand located in the extracellular matrix, whose biological functions in the heart remain poorly understood. In the current study we aimed to test the role of MFAP4 in cardiac remodeling.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              MFAP4\u2010deficient (MFAP4\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ) and wild\u2010type mice were subjected to aortic banding surgery and isoproterenol to establish models of cardiac remodeling. We also evaluated the functional effects of MFAP4 on cardiac hypertrophy, fibrosis, and cardiac electrical remodeling. The expression of MFAP4 was increased in the animal cardiac remodeling models induced by pressure overload and isoproterenol. After challenge of 8\u00a0weeks of aortic banding or 2\u00a0weeks of intraperitoneal isoproterenol, MFAP4\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice exhibited lower levels of cardiac fibrosis and fewer ventricular arrhythmias than wild\u2010type mice. However, there was no significant effect on cardiomyocyte hypertrophy. In addition, there was no significant difference in cardiac fibrosis severity, hypertrophy, or ventricular arrhythmia incidence between wild\u2010type\u2010sham and knockout\u2010sham mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These findings are the first to demonstrate that MFAP4 deficiency inhibits cardiac fibrosis and ventricular arrhythmias after challenge with 8\u00a0weeks of aortic banding or 2\u00a0weeks of intraperitoneal isoproterenol but does not significantly affect the hypertrophy response. In addition, MFAP4 deficiency had no significant effect on cardiac fibrosis, hypertrophy, or ventricular arrhythmia in the sham group in this study.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015307","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:23:01Z","timestamp":1598606581000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Deletion of Microfibrillar\u2010Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-7419","authenticated-orcid":false,"given":"Hui-bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan China"},{"name":"Department of Cardiology Three Gorges University People\u2019s Hospital The First People\u2019s Hospital of Yichang Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-1482","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Three Gorges University People\u2019s Hospital The First People\u2019s Hospital of Yichang Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-7369","authenticated-orcid":false,"given":"Wei","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan 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