{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:42:29Z","timestamp":1790502149748,"version":"4.1.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The aim of this study was to assess the relationship between serum lipoprotein (a) (Lp[a]) concentration and the requirement for peripheral artery disease (\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              ) operations or incidence of major adverse cardiovascular events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 1472 people with\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              presenting with intermittent claudication (n=355), abdominal aortic aneurysm (n=989) or critical limb ischemia (n=128) were prospectively recruited from 4 outpatient clinics in Australia. Lp(a) was measured in serum samples collected at recruitment using an immunoassay. Participants were followed for a median (interquartile range) of 2.4 (0.1\u20136.1) years to record requirement for any\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              operation, defined to include any open or endovascular\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              intervention (lower limb peripheral revascularization,\n              <jats:styled-content style=\"fixed-case\">abdominal aortic aneurysm<\/jats:styled-content>\n              repair, other aneurysm repair, or carotid artery revascularization). Myocardial infarctions, strokes, and deaths were also recorded. The association of Lp(a) with events was assessed using Cox proportional hazard analysis adjusting for traditional risk factors. Participants with Lp(a) \u226530\u00a0mg\/dL had a greater requirement for any\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              operation (hazard ratio, 1.20, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.02\u20131.41) and lower limb peripheral revascularization alone (\n              <jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content>\n              1.33, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.06\u20131.66) but no increased risk of\n              <jats:styled-content style=\"fixed-case\">major adverse cardiovascular events<\/jats:styled-content>\n              or all\u2010cause mortality. Lp(a) \u226550\u00a0mg\/dL and a 40\u00a0mg\/dL increase in Lp(a) were also associated with an increased risk of lower limb peripheral revascularization alone but not with other outcomes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In participants with\n              <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>\n              referred for hospital management those with high Lp(a) had greater requirement for lower limb peripheral revascularization but Lp(a) was not consistently associated with other clinical events.\n            <\/jats:p>\n          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