{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:09:32Z","timestamp":1792642172482,"version":"4.5.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"\n Background<\/jats:title>\n \n Although changes in left ventricular end\u2010systolic volume (\n LVESV<\/jats:styled-content>\n ), left ventricular end\u2010diastolic volume, and global circumferential strain occur during cancer treatment, the relationship of these changes to the 2\u2010year post\u2013cancer\u2010treatment measures of left ventricular ejection fraction (\n LVEF<\/jats:styled-content>\n ) are unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In a prospective, continuously recruited cohort of 95 patients scheduled to receive potentially cardiotoxic chemotherapy for breast cancer, lymphoma, or soft tissue sarcoma, measures of left ventricular end\u2010diastolic volume,\n LVESV<\/jats:styled-content>\n , global circumferential strain, and\n LVEF<\/jats:styled-content>\n were acquired via cardiac magnetic resonance imaging before and then 3 and 24\u00a0months after initiating treatment by individuals blinded to all patient identifiers. Participants had an average age of 54\u00b115\u00a0years; 68% were women, and 82% were of white race.\n LVEF<\/jats:styled-content>\n declined from 62\u00b17% to 58\u00b19% over the 24\u00a0months (\n P<\/jats:italic>\n <0.0001), with 42% of participants experiencing a >5% decline in\n LVEF<\/jats:styled-content>\n at 24\u00a0months. Predictors of a 24\u2010month >5% decline in\n LVEF<\/jats:styled-content>\n included the following factors from baseline to 3\u00a0months into treatment: (1) >3\u2010mL increases in\n LVESV<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.033), (2) >3\u2010mL increases in\n LVESV<\/jats:styled-content>\n or 10\u2010mL declines in left ventricular end\u2010diastolic volume with little change in\n LVESV<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.001), or (3) \u226510% deteriorations in global circumferential strain with little change in\n LVESV<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.036).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n During receipt of potentially cardiotoxic chemotherapy, increases in\n LVESV<\/jats:styled-content>\n , the absence of its deterioration during decreases of left ventricular end\u2010diastolic volume, or the deterioration of global circumferential strain without a marked decrease in\n LVESV<\/jats:styled-content>\n help identify those who will develop more permanent 2\u2010year declines in\n LVEF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.015400","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T05:06:10Z","timestamp":1579583170000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Simultaneous Left Ventricular Volume and Strain Changes During Chemotherapy Associate With 2\u2010Year Postchemotherapy Measures of Left Ventricular Ejection Fraction"],"prefix":"10.1161","volume":"9","author":[{"given":"Cynthia K.","family":"Suerken","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Ralph B.","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Virginia Commonwealth University Richmond VA"},{"name":"Pauley Heart Center Department of Internal Medicine at Virginia Commonwealth University Health Sciences Richmond VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle C.","family":"Mel\u00e9ndez","sequence":"additional","affiliation":[{"name":"Section on Cardiovascular Medicine and Pathology Section\u00a0on Comparative Medicine Department of Internal Medicine Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujethra","family":"Vasu","sequence":"additional","affiliation":[{"name":"Section on Cardiovascular Medicine and Pathology Section\u00a0on Comparative Medicine Department of Internal Medicine Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanetta S.","family":"Lamar","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wake Forest Baptist Medical Center Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gregory","family":"Hundley","sequence":"additional","affiliation":[{"name":"Section on Cardiovascular Medicine and Pathology Section\u00a0on Comparative Medicine Department of Internal Medicine Wake Forest School of Medicine Winston\u2010Salem NC"},{"name":"Pauley Heart Center Department of Internal Medicine at Virginia Commonwealth University Health Sciences Richmond VA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-66"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-016-0533-x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.02.008"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.06.004"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.072"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003682"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0373-3"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.017"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.012"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.08.005"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192065"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90986-6"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004560"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.035"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973321"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.02.008"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027930"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.015400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:00:45Z","timestamp":1715587245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.015400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,21]]}},"alternative-id":["10.1161\/JAHA.119.015400"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.015400","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"assertion":[{"value":"2019-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e015400"}}