{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:12:25Z","timestamp":1791551545302,"version":"4.3.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Risk stratification among patients with coronary artery disease (\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              ) is of considerable interest due to the potential to guide secondary preventive therapies. Thus, we evaluated the predictive value of soluble urokinase\u2010type plasminogen activator receptor (su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              ) levels for cardiovascular mortality and nonfatal myocardial infarction in patients with\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Plasma levels of su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              were measured in a cohort of 1703 patients with documented\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              as evidenced by coronary angiography\u2014including 626 patients with acute coronary syndrome and 1077 patients with stable angina pectoris. Cardiovascular death and\/or nonfatal myocardial infarction were defined as main outcome measures. During a median follow\u2010up of 3.5\u00a0years, su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              levels reliably predicted cardiovascular death or myocardial infarction in\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              , evidenced by survival curves stratified for tertiles of su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              levels. In Cox regression analyses, the hazard ratio for the prediction of cardiovascular death and\/or myocardial infarction was 2.19 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in the overall cohort and 2.56 in the acute coronary syndrome cohort (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Even after adjustment for common cardiovascular risk factors, renal function and the biomarkers C\u2010reactive protein, N\u2010terminal pro\u2010B\u2010type natriuretic peptide and high\u2010sensitivity troponin I su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              still enabled a reliable prediction of cardiovascular death or myocardial infarction with a hazard ratio of 1.61 (\n              <jats:italic>P<\/jats:italic>\n              =0.022) in the overall cohort and 2.22 (\n              <jats:italic>P<\/jats:italic>\n              =0.005) in the acute coronary syndrome cohort.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Su\n              <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\n              has a strong and independent prognostic value in secondary prevention settings, and thereby might represent a valuable biomarker for risk estimation in\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015452","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T09:00:22Z","timestamp":1587114022000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Cardio\u2010Renal Biomarker Soluble Urokinase\u2010Type Plasminogen Activator Receptor Is Associated With Cardiovascular Death and Myocardial Infarction in Patients With Coronary Artery Disease Independent of Troponin, C\u2010Reactive Protein, and Renal Function"],"prefix":"10.1161","volume":"9","author":[{"given":"Julius","family":"Nikorowitsch","sequence":"first","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Borchardt","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Lackner","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Medical Center Johannes Gutenberg University Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhein\u2010Main Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate B.","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, L\u00fcbeck, Kiel Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, L\u00fcbeck, Kiel Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research 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