{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:45:38Z","timestamp":1790214338810,"version":"4.1.0"},"reference-count":139,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p xml:lang=\"en\">\n            Genetic testing for hypertrophic cardiomyopathy (\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            ) is an established clinical technique, supported by 30\u00a0years of research into its genetic etiology. Although pathogenic variants are often detected in patients and used to identify at\u2010risk relatives, the effectiveness of genetic testing has been hampered by ambiguous genetic associations (yielding uncertain and potentially false\u2010positive results), difficulties in classifying variants, and uncertainty about genotype\u2010negative patients. Recent case\u2010control studies on rare variation, improved data sharing, and meta\u2010analysis of case cohorts contributed to new insights into the genetic basis of\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            . In particular, although research into new genes and mechanisms remains essential, reassessment of Mendelian genetic associations in\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            argues that current clinical genetic testing should be limited to a small number of validated disease genes that yield informative and interpretable results. Accurate and consistent variant interpretation has benefited from new standardized variant interpretation guidelines and innovative approaches to improve classification. Most cases lacking a pathogenic variant are now believed to indicate non\u2010Mendelian\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            , with more benign prognosis and minimal risk to relatives. Here, we discuss recent advances in the genetics of\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            and their application to clinical genetic testing together with practical issues regarding implementation. Although this review focuses on\n            <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>\n            , many of the issues discussed are also relevant to other inherited cardiac diseases.\n          <\/jats:p>","DOI":"10.1161\/jaha.119.015473","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T09:00:23Z","timestamp":1587200423000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-9980","authenticated-orcid":false,"given":"Francesco","family":"Mazzarotto","sequence":"first","affiliation":[{"name":"Cardiomyopathy Unit Careggi University Hospital Florence Italy"},{"name":"Cardiovascular Research Center Royal Brompton and Harefield NHS Foundation Trust London United Kingdom"},{"name":"National Heart and Lung Institute Imperial College London United Kingdom"},{"name":"Department of Clinical and Experimental Medicine University of Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"Cardiomyopathy Unit Careggi University Hospital Florence Italy"},{"name":"Department of Clinical and Experimental Medicine University of Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Boschi","sequence":"additional","affiliation":[{"name":"Cardiomyopathy Unit Careggi University Hospital Florence Italy"},{"name":"Genetic Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Girolami","sequence":"additional","affiliation":[{"name":"Cardiomyopathy Unit Careggi University Hospital Florence Italy"},{"name":"Department of Paediatric Cardiology Meyer Children's Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Poggesi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J. R.","family":"Barton","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Royal Brompton and Harefield NHS Foundation Trust London United Kingdom"},{"name":"National Heart and Lung Institute Imperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roddy","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology Heart Center Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.785"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.019"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.20.1.1"},{"issue":"4","key":"e_1_3_2_7_2","first-page":"3","article-title":"Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients","volume":"30","author":"Braunwald E","year":"1964","unstructured":"Braunwald E, Lambrew CT, Rockoff SD, Ross J, Morrow AG. Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30(suppl 4):3\u2013119.","journal-title":"Circulation"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911163212005"},{"key":"e_1_3_2_9_2","first-page":"389","article-title":"A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI\u2010L436, and CRI\u2010L329 on chromosome 14 at q11\u2010q12","volume":"47","author":"Solomon SD","year":"1990","unstructured":"Solomon SD, Geisterfer\u2010Lowrance AA, Vosberg HP, Hiller G, Jarcho JA, Morton CC, McBride WO, Mitchell AL, Bale AE, McKenna WJ. A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI\u2010L436, and CRI\u2010L329 on chromosome 14 at q11\u2010q12. Am J Hum Genet. 1990;47:389\u2013394.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90274-I"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114802"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0493-333"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90054-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0793-311"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-434"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6270"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-63"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-379"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050210"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6460"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009823200"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200872"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi146"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-018-0324-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9641"},{"key":"e_1_3_2_26_2","first-page":"787","article-title":"Glycogenosis type II: protein and DNA analysis in five South African families from various ethnic origins","volume":"44","author":"Van der Ploeg AT","year":"1989","unstructured":"Van der Ploeg AT, Hoefsloot LH, Hoogeveen\u2010Westerveld M, Petersen EM, Reuser AJ. Glycogenosis type II: protein and DNA analysis in five South African families from various ethnic origins. Am J Hum Genet. 1989;44:787\u2013793.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_27_2","first-page":"440","article-title":"Identification of the base\u2010pair substitution responsible for a human acid alpha glucosidase allele with lower \u201caffinity\u201d for glycogen (GAA 2) and transient gene expression in deficient cells","volume":"47","author":"Martiniuk F","year":"1990","unstructured":"Martiniuk F, Bodkin M, Tzall S, Hirschhorn R. Identification of the base\u2010pair substitution responsible for a human acid alpha glucosidase allele with lower \u201caffinity\u201d for glycogen (GAA 2) and transient gene expression in deficient cells. Am J Hum Genet. 1990;47:440\u2013445.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114027"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.7.1051"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380030204"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.029504"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033349"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0184-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106143442403"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.28.2.73"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380050302"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1132"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013354"},{"key":"e_1_3_2_39_2","first-page":"413","article-title":"A mild form of muscular glycogenosis in two brothers with alpha\u20101, 4\u2010glucosidase deficiency","volume":"205","author":"Zellweger H","year":"1965","unstructured":"Zellweger H, Brown BI, McCormick WF, Tu JB. A mild form of muscular glycogenosis in two brothers with alpha\u20101, 4\u2010glucosidase deficiency. Ann Paediatr. 1965;205:413\u2013437.","journal-title":"Ann Paediatr"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02998.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02185782"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3954.180"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.8.3301"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.51"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/35022604"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42128-5"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2375"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870754"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.119.002460"},{"key":"e_1_3_2_50_2","first-page":"3461","article-title":"Defining the genetic architecture of hypertrophic cardiomyopathy: re\u2010evaluating the role of non\u2010sarcomeric genes","volume":"38","author":"Walsh R","year":"2017","unstructured":"Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Loong CCW, Pua CJ, Raphael C, et\u00a0al. Defining the genetic architecture of hypertrophic cardiomyopathy: re\u2010evaluating the role of non\u2010sarcomeric genes. Eur Heart J. 2017;38:3461\u20133468.","journal-title":"Eur Heart J"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1143"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17892"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000056522.82563.5f"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.04.006"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.016"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6326"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.093"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11632"},{"key":"e_1_3_2_60_2","unstructured":"Exome Variant Server . Available at: http:\/\/evs.gs.washington.edu\/EVS\/. Accessed December 3 2018."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.112.962928"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.283"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.90"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.037661"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0046-0"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1406261"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq067"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300368"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.205"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-014-9774-8"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht439"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318223e2bd"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310987"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2013.2.1.36"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40246\u2010015\u20100031\u20105"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.247"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.117.001768"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.10.001"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181465"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.187"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.078"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-011-9268-3"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-016-9673-5"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.254698"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-014-0067-8"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1507092"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.08.008"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200009000-00009"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.14"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23643"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.258"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23665"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.04.003"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23626"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0616-z"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.26"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606950113"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2018.3"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.218"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.210"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033200"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3703"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.08.016"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180685"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy249"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.08.008"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032273"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035028"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0461-z"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.5333"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0379-x"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.190"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0039-z"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504203321603"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804303381802"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.059"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000331"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005311"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.01.025"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306387"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001660"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001620"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303939"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.038"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.44"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.79"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.118.002368"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.068"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223834"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.112.965277"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1211"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1687"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0704-9"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001666"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001685"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.117.001749"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0192-y"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.015473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:55:55Z","timestamp":1715601355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.015473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":139,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4,21]]}},"alternative-id":["10.1161\/JAHA.119.015473"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.015473","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"assertion":[{"value":"2020-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e015473"}}