{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T08:42:10Z","timestamp":1782636130568,"version":"3.54.5"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Evidence that a vegetarian diet rich in antioxidants contributes to cardiovascular health are growing, however, the underlying molecular mechanisms remain unknown. HO\u20101 (heme\u2010oxygenase\u20101), a marker of adaptive response, is protective against oxidative stress and has shown cardioprotective effects. Therefore, we evaluated circulating\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 levels and the effect of plasma from omnivorous and vegetarians in endothelial cells (human umbilical vein endothelial cells) on modulating\n              <jats:styled-content style=\"fixed-case\">NRF2 (nuclear factor erythroid 2\u2010like 2)\/HO<\/jats:styled-content>\n              \u20101 and nitric oxide production.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From 745 participants initially recruited, 44 omnivorous and 44 vegetarian men matched by age and absence of cardiovascular risk factors and diseases were included in this study. Circulating\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 was measured using\n              <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n              and human umbilical vein endothelial cells were incubated with plasma from omnivorous and vegetarians. Higher circulating\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 concentrations were found in omnivorous compared with vegetarians. Plasma from omnivorous and not from vegetarians induced\n              <jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>\n              2\/\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 and nitric oxide production in human umbilical vein endothelial cells, and increased reactive oxygen species production and caspase activity after incubation with stressor stimulus.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We suggest that\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 induction in omnivorous may indicate a pro\u2010oxidative status since\n              <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\n              \u20101 is activated under oxidative stress a state not seen in vegetarians.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015576","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T09:21:33Z","timestamp":1591694493000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association of Omnivorous and Vegetarian Diets With Antioxidant Defense Mechanisms in Men"],"prefix":"10.1161","volume":"9","author":[{"given":"Naiara","family":"Cinegaglia","sequence":"first","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University \u2013 IBB\/UNESP Botucatu, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Acosta\u2010Navarro","sequence":"additional","affiliation":[{"name":"Heart Institute InCor University of S\u00e3o Paulo Medical School Hospital S\u00e3o Paulo 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