{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:28:45Z","timestamp":1785875325171,"version":"3.56.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The association between mitral valve prolapse (MVP) and sudden death remains controversial. We aimed to describe histopathological changes in individuals with autopsy\u2010determined isolated\n              <jats:styled-content style=\"fixed-case\">MVP<\/jats:styled-content>\n              (\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              ) and sudden death and document cardiac arrest rhythm.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The Australian National Coronial Information System database was used to identify cases of\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              between 2000 and 2018. Histopathological changes in\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              and sudden death were compared with 2 control cohorts matched for age, sex, height, and weight (1 group with noncardiac death and 1 group with cardiac death). Data linkage with ambulance services provided cardiac arrest rhythm for\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              cases. From 77\u00a0221 cardiovascular deaths in the National Coronial Information System database, there were 376 cases with\n              <jats:styled-content style=\"fixed-case\">MVP<\/jats:styled-content>\n              . Individual case review yielded 71 cases of\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              . Mean age was 49\u00b118\u00a0years, and 51% were women. Individuals with\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              had higher cardiac mass (447\u00a0g versus 355\u00a0g;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with noncardiac death, but similar cardiac mass (447\u00a0g versus 438\u00a0g;\n              <jats:italic>P<\/jats:italic>\n              =0.64) compared with cardiac death. Individuals with\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              had larger mitral valve annulus compared with noncardiac death (121\u00a0versus 108\u00a0mm;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and cardiac death\u00a0(121\u00a0versus 110\u00a0mm;\n              <jats:italic>P<\/jats:italic>\n              =0.002), and more left ventricular fibrosis (79% versus 38%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with noncardiac death controls. In those with\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              and witnessed cardiac arrest, 94% had ventricular fibrillation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Individuals with\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              and sudden death have increased cardiac mass, mitral annulus size, and left ventricular fibrosis compared with a matched cohort, with cardiac arrest caused by ventricular fibrillation. The histopathological changes in\n              <jats:styled-content style=\"fixed-case\">iMVP<\/jats:styled-content>\n              may provide the substrate necessary for development of malignant ventricular arrhythmias.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015587","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T09:00:34Z","timestamp":1585731634000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Characteristic Histopathological Findings and Cardiac Arrest Rhythm in Isolated Mitral Valve Prolapse and Sudden Cardiac Death"],"prefix":"10.1161","volume":"9","author":[{"given":"Hui\u2010Chen","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiology Austin Health and University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah 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