{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:39:32Z","timestamp":1784918372935,"version":"3.55.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Women with signs and symptoms of ischemia and no obstructive coronary artery disease often have evidence of diastolic dysfunction. Oxidative stress (\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              ) is associated with cardiovascular risk factors and adverse outcomes. The relationship between systemic\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              and diastolic dysfunction is unknown.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A subgroup of women (n=75) with suspected ischemia and no obstructive coronary artery disease who had both cardiac magnetic resonance imaging and\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              measurements were enrolled in the\n              <jats:styled-content style=\"fixed-case\">WISE<\/jats:styled-content>\n              \u2010\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              (Women Ischemia Syndrome Evaluation\u2014Coronary Vascular Dysfunction) study. Left ventricular end\u2010diastolic pressure was measured invasively. Left ventricular end\u2010diastolic volume and peak filling rate were assessed using cardiac magnetic resonance imaging. Aminothiol levels of plasma cystine and glutathione were measured as markers of\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              . Spearman correlation and linear regression analyses were conducted. The group mean age was 54\u00b111\u00a0years, and 61% had a resting left ventricular end\u2010diastolic pressure &gt;12\u00a0mm\u00a0Hg. Cystine levels correlated negatively with the peak filling rate (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.31,\n              <jats:italic>P<\/jats:italic>\n              =0.007) and positively with left ventricular end\u2010diastolic pressure (\n              <jats:italic>r<\/jats:italic>\n              =0.25;\n              <jats:italic>P<\/jats:italic>\n              =0.038), indicating that increased\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              was associated with diastolic dysfunction. After multivariate adjustment including multiple known risk factors for diastolic dysfunction and cardiovascular medications, cystine levels continued to be associated with peak filling rate (\u03b2=\u22120.27,\n              <jats:italic>P<\/jats:italic>\n              =0.049) and left ventricular end\u2010diastolic pressure (\u03b2=0.25;\n              <jats:italic>P<\/jats:italic>\n              =0.035). Glutathione levels were not associated with indices of diastolic function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              , measured by elevated levels of cystine, is associated with diastolic dysfunction in women with evidence of ischemia and no obstructive coronary artery disease, indicating the role of\n              <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n              in patients with ischemia and no obstructive coronary artery disease. Its role in the progression of heart failure with preserved ejection fraction should be explored further.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015602","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T09:01:18Z","timestamp":1588842078000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Oxidative Stress Is Associated With Diastolic Dysfunction in Women With Ischemia With No Obstructive Coronary Artery Disease"],"prefix":"10.1161","volume":"9","author":[{"given":"Mohamad","family":"Raad","sequence":"first","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"AlBadri","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wei","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars\u2010Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Maughan","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars\u2010Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adit","family":"Gadh","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars\u2010Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Thomson","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars\u2010Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care and Sleep Medicine Department of Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshed A.","family":"Quyyumi","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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