{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:46Z","timestamp":1792597246266,"version":"4.5.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Approximately 1 in 6 adolescents report regular binge alcohol consumption, and we hypothesize it affects heart growth during this period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Adolescent, genetically diverse, male Wistar rats were gavaged with water or ethanol once per day for 6\u00a0days. In vivo structure and function were assessed before and after exposure. Binge alcohol exposure in adolescence significantly impaired normal cardiac growth but did not affect whole\u2010body growth during adolescence, therefore this pathology was specific to the heart. Binge rats also exhibited signs of accelerated pathological growth (concentric cellular hypertrophy and thickening of the myocardial wall), suggesting a global reorientation from physiologic to pathologic growth. Binge rats compensated for their smaller filling volumes by increasing systolic function and sympathetic stimulation. Consequently, binge alcohol exposure increased PKA (protein kinase A) phosphorylation of troponin I, inducing myofilament calcium desensitization. Binge alcohol also impaired in vivo relaxation and increased titin\u2010based cellular stiffness due to titin phosphorylation by PKC\u03b1 (protein kinase C \u03b1). Mechanistically, alcohol inhibited extracellular signal\u2010related kinase activity, a nodal signaling kinase activating physiology hypertrophy. Thus, binge alcohol exposure depressed genes involved in growth. These cardiac structural alterations from binge alcohol exposure persisted through adolescence even after cessation of ethanol exposure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Alcohol negatively impacts function in the adult heart, but the adolescent heart is substantially more sensitive to its effects. This difference is likely because adolescent binge alcohol impedes the normal rapid physiological growth and reorients it towards pathological hypertrophy. Many adolescents regularly binge alcohol, and here we report a novel pathological consequence as well as mechanisms involved.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015611","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T09:06:06Z","timestamp":1587546366000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth"],"prefix":"10.1161","volume":"9","author":[{"given":"Lizhuo","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnnaDorothea","family":"Asimes","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerachat","family":"Kampaengsri","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Heroux","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Zlobin","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Hiske","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni R.","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-2860","authenticated-orcid":false,"given":"Jonathan A.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology Loyola University Chicago Stritch School of Medicine Maywood IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"(SAMHSA) SAaMHSA . 2015 national survey on drug use and health (NSDUH). 2015."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6506a1","article-title":"Youth risk behavior surveillance\u2014United States, 2015","volume":"65","author":"Kann L","year":"2016","unstructured":"Kann L, McManus T, Harris WA, Shanklin SL, Flint KH, Hawkins J, Queen B, Lowry R, Olsen EO, Chyen D, et\u00a0al. 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