{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:53:14Z","timestamp":1790473994598,"version":"4.1.0"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">A 2018 American Heart Association science advisory indicated that, pending further research, artificially sweetened beverages (ASBs) may be an appropriate initial replacement for sugar\u2010sweetened beverages (SSBs) during transition to unsweetened beverages (USBs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We randomly assigned 203 adults (121 males, 82 females; 91.6% retention), who habitually consumed SSBs, to 3 groups and delivered free SSBs, ASBs, or USBs to their homes for 12\u00a0months. Outcomes included serum triglyceride to high\u2010density lipoprotein cholesterol ratio (primary), body weight, and sweet taste preference (experimental assessment, 0%\u201318% sucrose solutions). Change in serum triglyceride to high\u2010density lipoprotein cholesterol ratio was not different between groups. Although overall change in weight also was not different between groups, we found effect modification (\n                      <jats:italic>P<\/jats:italic>\n                      =0.006) by central adiposity. Among participants in the highest tertile of baseline trunk fat but not other tertiles, weight gain was greater (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002) for the SSB (4.4\u00b11.0\u00a0kg, estimate\u00b1SE) compared with ASB (0.5\u00b10.9\u00a0kg) or USB (\u22120.2\u00b10.9\u00a0kg) group. Both sweetness threshold (\u20131.0\u00b10.2% m\/v;\n                      <jats:italic>P<\/jats:italic>\n                      =0.005) and favorite concentration (\u20132.3\u00b10.4% m\/v;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) decreased in the USB group; neither changed in the SSB group. In the ASB group, sweetness threshold did not change, and favorite concentration decreased (\u20131.1\u00b10.5% m\/v;\n                      <jats:italic>P<\/jats:italic>\n                      =0.02). Pairwise comparison between the ASB and USB groups indicated a difference in sweetness threshold (\n                      <jats:italic>P<\/jats:italic>\n                      =0.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Replacing SSBs with noncaloric beverages for 12\u00a0months did not affect serum triglyceride to high\u2010density lipoprotein cholesterol ratio. Among individuals with central adiposity, replacing SSBs with either ASBs or USBs lowered body weight. However, USBs may have the most favorable effect on sweet taste preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; unique identifier: NCT01295671.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.015668","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T05:14:24Z","timestamp":1595394864000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Effects of Sugar\u2010Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-9859","authenticated-orcid":false,"given":"Cara B.","family":"Ebbeling","sequence":"first","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Steltz","sequence":"additional","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle L.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Shape Up Somerville City of Somerville MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"New Balance Foundation Obesity Prevention Center Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192627"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000439"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058362"},{"key":"e_1_3_2_5_2","volume-title":"Dietary Guidelines for Americans 2015 \u2010 2020","author":"U.S. Department of Health and Human Services and U.S. Department of Agriculture","year":"2015","unstructured":"U.S. Department of Health and Human Services and U.S. Department of Agriculture . 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