{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:19:10Z","timestamp":1794572350522,"version":"4.9.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Leukocyte\u2010directed biosynthesis of specialized proresolving mediators (SPMs) orchestrates physiological inflammation after myocardial infarction. Deficiency of SPMs drives pathological and nonresolving inflammation, leading to heart failure (HF). Differences in SPMs and inflammatory responses caused by sex\u2010specific differences are of interest. We differentiated leukocyte\u2010directed biosynthesis of lipid mediators in male and female mice, focusing on leukocyte populations, structural remodeling, functional recovery, and survival rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Risk\u2010free male and female C57BL\/6 mice were selected as na\u00efve controls or subjected to myocardial infarction surgery. Molecular and cellular mechanisms that differentiate survival, heart function, and structure and leukocyte\u2010directed lipid mediators were quantified to describe physiological inflammation after myocardial infarction. Female mice show improved survival in acute HF but no statistical difference during chronic HF compared with male mice. Female mice improved survival is marked with functional recovery and limited remodeling compared with male mice. Male and female mice are similarly responsive to arachidonate lipoxygenase (\n                      <jats:italic>LOX\u20105<\/jats:italic>\n                      ,\n                      <jats:italic>LOX\u201012<\/jats:italic>\n                      ,\n                      <jats:italic>LOX<\/jats:italic>\n                      \u201015) or cyclooxygenase (\n                      <jats:italic>COX\u20101<\/jats:italic>\n                      ,\n                      <jats:italic>COX\u20102<\/jats:italic>\n                      ) in acute HF and particularly male infarcted heart had overall increased SPMs. Female cardiac healing is marked with the biosynthesis of differential p450\u2010derived product, particularly 11,12 epoxyeicosatrienoic acid in acute HF. A sex\u2010specific difference of dendritic cells in acute HF is distinct, with limited changes in chronic HF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac repair is marked with increased SPM biosynthesis in male mice and amplified epoxyeicosatrienoic acid in female mice. Female mice showed improved survival, functional recovery, and limited remodeling, which are signs of fine\u2010tuned physiological inflammation after myocardial infarction. These results rationalize the sex\u2010specific precise therapies and differential treatments in acute and chronic HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.015672","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T05:06:08Z","timestamp":1587013568000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice"],"prefix":"10.1161","volume":"9","author":[{"given":"Amanda B.","family":"Pullen","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences Department of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhara","family":"Kain","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences Department of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative and Pain Medicine Brigham and Women\u2019s Hospital Harvard Medical School, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-9354","authenticated-orcid":false,"given":"Ganesh V.","family":"Halade","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences Department of Medicine University of South Florida Tampa 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