{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:30:45Z","timestamp":1792042245701,"version":"4.4.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">VEGF\u2010D (vascular endothelial growth factor D) and VEGF\u2010C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF\u2010C level is inversely and independently associated with all\u2010cause mortality in patients with suspected or known coronary artery disease. We investigated whether VEGF\u2010D had distinct relationships with mortality and cardiovascular events in those patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We performed a multicenter, prospective cohort study of 2418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. The serum level of VEGF\u2010D was measured. The primary outcome was all\u2010cause death. The secondary outcomes were cardiovascular death and major adverse cardiovascular events defined as a composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke. During the 3\u2010year follow\u2010up, 254 patients died from any cause, 88 died from cardiovascular disease, and 165 developed major adverse cardiovascular events. After adjustment for possible clinical confounders, cardiovascular biomarkers (N\u2010terminal pro\u2010B\u2010type natriuretic peptide, cardiac troponin\u2010I, and high\u2010sensitivity C\u2010reactive protein), and VEGF\u2010C, the VEGF\u2010D level was significantly associated with all\u2010cause death and cardiovascular death but not with major adverse cardiovascular events.. Moreover, the addition of VEGF\u2010D, either alone or in combination with VEGF\u2010C, to the model with possible clinical confounders and cardiovascular biomarkers significantly improved the prediction of all\u2010cause death but not that of cardiovascular death or major adverse cardiovascular events. Consistent results were observed within patients over 75\u00a0years old.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with suspected or known coronary artery disease undergoing elective coronary angiography, an elevated VEGF\u2010D value seems to independently predict all\u2010cause mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015761","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T09:10:20Z","timestamp":1587546620000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Distinct Characteristics of VEGF\u2010D and VEGF\u2010C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-224X","authenticated-orcid":false,"given":"Hiromichi","family":"Wada","sequence":"first","affiliation":[{"name":"Division of Translational Research National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research National Hospital Organization Saitama Hospital Wako Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morihiro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Ajiro","sequence":"additional","affiliation":[{"name":"Division of Clinical Research National Hospital 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