{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:15:20Z","timestamp":1790280920251,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Evidence regarding the relationships among high plasma triglycerides (TG), all\u2010cause mortality, and atherosclerotic cardiovascular disease (ASCVD) events in low\u2010to\u2010moderate risk individuals is limited. The aim of this study was to determine whether the presence of high TG levels influences the risk of all\u2010cause mortality and ASCVD events in a population cohort followed in the real\u2010world clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A retrospective longitudinal cohort analysis using administrative databases of 3 Italian Local Health Units was performed. All individuals with at least one TG measurement between January 1, 2010 and December 31, 2015 were followed through December 2016. Outcome measures included incident ASCVD events and all\u2010cause mortality. Individuals with normal TG levels (&lt;150\u00a0mg\/dL) were compared with those with high (150\u2013500\u00a0mg\/dL) and very high TG (&gt;500\u00a0mg\/dL). 158\u00a0042 individuals (142\u00a0289 with normal, 15\u00a0558 with high, and 195 with very high TG) were considered. In the whole cohort, the overall incidence rates of ASCVD and all\u2010cause mortality were 7.2 and 17.1 per 1000 person\u2010years, respectively. After multivariate adjustment for potential confounders, individuals with high and very high TG showed a significantly increased risk of all\u2010cause mortality (hazard ratio [HR]=1.49 [95% confidence interval (CI) 1.36\u20131.63],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001, and HR=3.08 [95% CI 1.46\u20136.50],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01, respectively) and incident ASCVD events (HR=1.61 [95% CI 1.43\u20131.82],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001, and HR=2.30 [95% CI 1.02\u20135.18],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05, respectively) as compared to those with normal TG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Moderate\u2010to\u2010severe elevation of TG is associated with a significantly increased risk of all\u2010cause mortality and ASCVD events in a large cohort of low\u2010to\u2010moderate cardiovascular risk individuals in a real\u2010world clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.015801","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T05:18:55Z","timestamp":1600665535000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Association of Hypertriglyceridemia with All\u2010Cause Mortality and Atherosclerotic Cardiovascular Events in a Low\u2010Risk Italian Population: The TG\u2010REAL Retrospective Cohort Analysis"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-0883","authenticated-orcid":false,"given":"Marcello","family":"Arca","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University of Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-2022","authenticated-orcid":false,"given":"Chiara","family":"Veronesi","sequence":"additional","affiliation":[{"name":"CliCon Srl, Health Economics and Outcomes Research Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-4667","authenticated-orcid":false,"given":"Laura","family":"D\u2019Erasmo","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University of Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Borghi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-2234","authenticated-orcid":false,"given":"Furio","family":"Colivicchi","sequence":"additional","affiliation":[{"name":"Cardiology Division Emergency Department San Filippo Neri Hospital ASL Roma 1 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano Maria","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medical Sciences \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Hospital University of Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovambattista","family":"Desideri","sequence":"additional","affiliation":[{"name":"Department of Life, 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