{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:30:31Z","timestamp":1781530231498,"version":"3.54.1"},"reference-count":104,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Pigs\/bovines share common antigens with humans: \u03b1\u2010Gal, present in all pigs\/bovines close to the human B\u2010antigen; and AH\u2010histo\u2010blood\u2010group antigen, identical to human AH\u2010antigen and present only in some animals. We investigate the possible impact of patients\u2019 ABO blood group on bioprosthesis structural valve degeneration (SVD) through calcification\/pannus\/tears\/perforations for patients \u226460\u00a0years at implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a single\u2010center study (Paris, France) that included all degenerative bioprostheses explanted between 1985 and 1998, mostly porcine bioprostheses (Carpentier\u2010Edwards second\/third porcine bioprostheses) and some bovine bioprostheses. For the period 1998 to 2014, only porcine bioprostheses with longevity \u226513\u00a0years were included (total follow\u2010up \u226529\u00a0years). Except for blood groups, important predictive factors for SVD were prospectively collected (age at implantation\/longevity\/number\/site\/sex\/SVD types) and analyzed using logistic regression. All variables were available for 500 explanted porcine bioprostheses. By multivariate analyses, the A group was associated with an increased risk of: tears (odds ratio[OR], 1.61;\n              <jats:italic>P<\/jats:italic>\n              =0.026); pannus (OR, 1.5;\n              <jats:italic>P<\/jats:italic>\n              =0.054), pannus with tears (OR, 1.73;\n              <jats:italic>P<\/jats:italic>\n              =0.037), and tendency for lower risk of: calcifications (OR, 0.63;\n              <jats:italic>P<\/jats:italic>\n              =0.087) or isolated calcification (OR, 0.67;\n              <jats:italic>P<\/jats:italic>\n              =0.17). A\u2010antigen was associated with lower risk of perforations (OR 0.56;\n              <jats:italic>P<\/jats:italic>\n              =0.087). B\u2010group patients had an increased risk of: perforations (OR, 1.73;\n              <jats:italic>P<\/jats:italic>\n              =0.043); having a pannus that was calcified (OR, 3.0,\n              <jats:italic>P<\/jats:italic>\n              =0.025). B\u2010antigen was associated with a propensity for calcifications in general (OR, 1.34;\n              <jats:italic>P<\/jats:italic>\n              =0.25).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patient\u2019s ABO blood group is associated with specific SVD types. We hypothesize that carbohydrate antigens, which may or may not be common to patient and animal bioprosthetic tissue, will determine a patient\u2019s specific immunoreactivity with respect to xenograft tissue and thus bioprosthesis outcome in terms of SVD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015909","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T09:01:59Z","timestamp":1595494919000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Possible Link Between the ABO Blood Group of Bioprosthesis Recipients and Specific Types of Structural Degeneration"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-8175","authenticated-orcid":false,"given":"Olivier","family":"Schussler","sequence":"first","affiliation":[{"name":"Deparments of Cardiovascular Surgery and Cardiovascular Research Laboratory Geneva University Hospitals and Faculty of Medicine Geneva Switzerland"},{"name":"Service de Chirurgie Thoracique H\u00f4pitaux Universitaire de StrasbourgParis University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermine","family":"Lila","sequence":"additional","affiliation":[{"name":"Biosurgical Research Lab (Carpentier Foundation) APHPGeorges PompidouEuropean Georges Pompidou Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Ottawa Heart InstituteUniversity of Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ruel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Ottawa Heart InstituteUniversity of Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Lecarpentier","sequence":"additional","affiliation":[{"name":"Centre de Recherche Clinique Grand H\u00f4pital de l\u2019Est Francilien (GHEF) Meaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Biosurgical Research Lab (Carpentier Foundation) APHPGeorges PompidouEuropean Georges Pompidou Hospital Paris France"},{"name":"Division of Cardiac Surgery and Research Laboratory European HospitalEuropean Georges Pompidou Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.164"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01097-2"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.09.030"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.43"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03190.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.003"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.1874"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.002"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.715"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000590"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.12.082"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000372"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12044"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708150-00032"},{"key":"e_1_3_1_16_2","first-page":"655","article-title":"Alpha\u2010galactosyl epitopes on glycoproteins of porcine renal extracellular matrix","volume":"57","author":"Maruyama S","year":"2000","unstructured":"Maruyama S, Cantu E III, Galili U, D'Agati V, Godman G, Stern DM, Andres G. 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