{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:16:55Z","timestamp":1763018215080,"version":"3.41.2"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ticagrelor reduces ischaemic end points in acute coronary syndromes. However, outcomes of ticagrelor versus clopidogrel in real\u2010world patients with acute coronary syndromes treated with percutaneous coronary intervention (PCI) remain unclear. We sought to examine whether treatment with ticagrelor is superior to clopidogrel in unselected patients with acute coronary syndromes treated with PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for PCI performed in V\u00e4stra G\u00f6taland County, Sweden. The database contains information about all PCI performed at 5 hospitals (\u223c20% of all data in SCAAR). All procedures between January 2005 and January 2015 for unstable angina\/non\u2012ST\u2010segment\u2012elevation myocardial infarction and ST\u2010segment\u2012elevation myocardial infarction were included. We used instrumental variable 2\u2010stage least squares regression to adjust for confounders. The primary combined end point was mortality or stent thrombosis at 30\u00a0days, secondary end points were mortality at 30\u00a0days and 1\u2010year, stent thrombosis at 30\u00a0days, in\u2010hospital bleeding, in\u2010hospital neurologic complications and long\u2010term mortality. A total of 15\u00a0097 patients were included in the study of which 2929 (19.4%) were treated with ticagrelor. Treatment with ticagrelor was not associated with a lower risk for the primary end point (adjusted odds ratio [aOR], 1.20; 95% CI, 0.87\u20131.61;\n              <jats:italic>P<\/jats:italic>\n              =0.250). Estimated risk of death at 30 days (aOR, 1.18; 95% CI, 0.88\u20131.64;\n              <jats:italic>P<\/jats:italic>\n              =0.287) and at 1\u2010year (aOR, 1.28; 95% CI, 0.86\u20131.64;\n              <jats:italic>P<\/jats:italic>\n              =0.556) was not different between the groups. The risk of in\u2010hospital bleeding was higher with ticagrelor (aOR, 2.88; 95% CI, 1.53\u20135.44;\n              <jats:italic>P<\/jats:italic>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this observational study, treatment with ticagrelor was not superior to clopidogrel in patients with acute coronary syndromes treated with PCI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.015990","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T09:07:01Z","timestamp":1594717621000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Ticagrelor is Not Superior to Clopidogrel in Patients With Acute Coronary Syndromes Undergoing PCI: A Report from Swedish Coronary Angiography and Angioplasty Registry"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-5360","authenticated-orcid":false,"given":"Sebastian","family":"V\u00f6lz","sequence":"first","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petur","family":"Petursson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Odenstedt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ioanes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg 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