{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:52:51Z","timestamp":1760921571299,"version":"3.41.2"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left ventricular assist devices (LVADs) improve outcomes in patients with end\u2010stage heart failure and are increasingly implanted for destination therapy. We describe dynamic estimates of event\u2010free survival with conditional survival probabilities in a destination therapy LVAD population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 8245 adult patients in INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) implanted with a continuous\u2010flow destination therapy LVAD. The composite primary end point was death, device exchange or removal, or heart transplantation. Conditional survival probabilities were calculated and stratified by implantation characteristics and nonfatal adverse events experienced within the first year after implant. Probabilities of surviving an additional 1 to 3\u00a0years were numerically higher after longer prior event\u2010free survival. INTERMACS profile 1, extracorporeal membrane oxygenation support, prior or concomitant surgery, and dialysis within 48\u00a0hours of implantation were associated with significantly lower event\u2010free survival in the first year but did not impact event\u2010free survival beyond then. For patients who experienced a nonfatal adverse event within the first year, subsequent 1\u2010year conditional survival was lower than in the absence of that event for stroke (65% [95% CI, 57%\u201373%] versus 75% [95% CI, 73%\u201377%];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), device\u2010related infection (64% [95% CI 57%\u201371%] versus 76% [95% CI, 74%\u201378%];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and pump thrombosis or malfunction (64% [95% CI, 57%\u201370%] versus 76% [95% CI, 74%\u201378%];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Conditional survival in patients with destination therapy LVADs improves over time, even for patients with unfavorable implantation characteristics. However, LVAD\u2010related complications including stroke, device\u2010related infection, and pump thrombosis or malfunction have an enduring negative influence on dynamic estimates of long\u2010term prognosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.016203","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:18:57Z","timestamp":1594372737000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Dynamic Forecasts of Survival for Patients Living With Destination Left Ventricular Assist Devices: Insights From INTERMACS"],"prefix":"10.1161","volume":"9","author":[{"given":"Katherine C.","family":"Michelis","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Peltz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3836","authenticated-orcid":false,"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W. 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