{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:59:54Z","timestamp":1789235994950,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Evidence\u2010based medication adherence rates after a myocardial infarction are low. We hypothesized that 90\u2010day prescriptions are underused and may lead to higher evidence\u2010based medication adherence compared with 30\u2010day fills.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We examined patients with myocardial infarction treated with percutaneous coronary intervention between 2011 and 2015 in the National Cardiovascular Data Registry. Linking to Symphony Health pharmacy data, we described the prevalence of patients filling 30\u2010day versus 90\u2010day prescriptions of statins, \u03b2\u2010blockers, angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, and P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitors after discharge. We compared 12\u2010month medication adherence rates by evidence\u2010based medication class and prescription days' supply and rates of medication switches and dosing changes. Among 353\u00a0259 patients with myocardial infarction treated with percutaneous coronary intervention, 90\u2010day evidence\u2010based medication fill rates were low: 13.0% (statins), 12.3% (\u03b2\u2010blockers), 14.6% (angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers), and 9.7% (P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitors). Patients filling 90\u2010day prescriptions were more likely older (median 69 versus 62\u00a0years) with a history of prior myocardial infarction (25.0% versus 17.9%) or percutaneous coronary intervention (30.3% versus 19.5%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01 for all) than patients filling 30\u2010day prescriptions. The 12\u2010month adherence rates were higher for patients who filled 90\u2010day versus 30\u2010day supplies: statins, 83.1% versus 75.3%; \u03b2\u2010blockers, 72.7% versus 62.9%; angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, 71.1% versus 60.9%; and P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitors, 78.5% versus 66.6% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01 for all). Medication switches and dosing changes within 12\u00a0months were infrequent for patients filling 30\u2010day prescriptions\u201414.7% and 0.3% for 30\u2010day P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitor fills versus 6.3% and 0.2% for 90\u2010day fills, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients who filled 90\u2010day prescriptions had higher adherence and infrequent medication changes within 1\u00a0year after discharge. Ninety\u2010day prescription strategies should be encouraged to improve post\u2013myocardial infarction medication adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.119.016215","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T05:02:09Z","timestamp":1608526929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Difference in Medication Adherence Between Patients Prescribed a 30\u2010Day Versus 90\u2010Day Supply After Acute Myocardial Infarction"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-2393","authenticated-orcid":false,"given":"Jennifer A.","family":"Rymer","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Fonseca","sequence":"additional","affiliation":[{"name":"AstraZeneca Wilmington DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durgesh D.","family":"Bhandary","sequence":"additional","affiliation":[{"name":"AstraZeneca Wilmington DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Kumar","sequence":"additional","affiliation":[{"name":"Symphony Health Plymouth Meeting PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem D.","family":"Khan","sequence":"additional","affiliation":[{"name":"AstraZeneca Wilmington DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318235eb4d"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618066"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706820"},{"key":"e_1_3_2_5_2","first-page":"e498","article-title":"Medication adherence and readmission in Medicare myocardial infarction","volume":"20","author":"Zhang Y","year":"2014","unstructured":"Zhang Y, Kaplan CM, Baik SH, Chang CCH, Lave JR. Medication adherence and readmission in Medicare myocardial infarction. Am J Manag Care. 2014;20:e498\u2013e505.","journal-title":"Am J Manag Care"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.09.014"},{"key":"e_1_3_2_7_2","first-page":"e427","article-title":"Medication adherence for 90\u2010day quantities of medication dispensed through retail and mail order pharmacies","volume":"17","author":"Khandelwal N","year":"2011","unstructured":"Khandelwal N, Duncan I, Rubenstein E, Ahmed T, Pegus C, Murphy P, Kudrak KE. Medication adherence for 90\u2010day quantities of medication dispensed through retail and mail order pharmacies. Am J Manag Care. 2011;17:e427\u2013e434.","journal-title":"Am J Manag Care"},{"key":"e_1_3_2_8_2","unstructured":"Zhang L. Medication adherence among mail\u2010order pharmacy users versus retail pharmacy users with 90\u2010day prescription fills. Presented at the Academy of Managed Care Pharmacy 2015 Annual Meeting San Diego CA."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.200261"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01372-9"},{"key":"e_1_3_2_11_2","unstructured":"Increasing adherence by prescribing 90\u2010day supplies of medication. Available at: https:\/\/www1.nyc.gov\/assets\/doh\/downloads\/pdf\/csi\/csi\u2010map\u2010med\u2010fact\u2010sheet.pdf. Accessed May 5 2018."},{"key":"e_1_3_2_12_2","unstructured":"Wellmark Blue Cross Blue Shield . 90\u2010day prescription fills benefit your employees. Available at: https:\/\/www.wellmark.com\/blue\u2010at\u2010work\/insights\/90\u2010day\u2010prescription\u2010refills. Accessed July 16 2020."},{"key":"e_1_3_2_13_2","first-page":"785","article-title":"Community pharmacy automatic refill program improves adherence to maintenance therapy and reduces wasted medication","volume":"21","author":"Matlin OS","year":"2015","unstructured":"Matlin OS, Kymes SM, Averbukh A, Choudhry NK, Brennan TA, Bunton A, Ducharme TA, Simmons PD, Shrank WH. Community pharmacy automatic refill program improves adherence to maintenance therapy and reduces wasted medication. Am J Manag Care. 2015;21:785\u2013791.","journal-title":"Am J Manag Care"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.5600\/mmrr.002.03.A04"},{"key":"e_1_3_2_15_2","first-page":"141","article-title":"Adherence to chronic medication therapy associated with 90\u2010day supplies compared with 30\u2010day supplies","volume":"16","author":"Hermes M","year":"2010","unstructured":"Hermes M, Gleason PP, Starner CI. Adherence to chronic medication therapy associated with 90\u2010day supplies compared with 30\u2010day supplies. J Manag Care Pharm. 2010;16:141\u2013142.","journal-title":"J Manag Care Pharm"},{"key":"e_1_3_2_16_2","unstructured":"Drug plan coverage rules. Available at: https:\/\/www.medicare.gov\/drug\u2010coverage\u2010part\u2010d\/what\u2010medicare\u2010part\u2010d\u2010drug\u2010plans\u2010cover\/drug\u2010plan\u2010coverage\u2010rules. Accessed September 20 2018."},{"key":"e_1_3_2_17_2","unstructured":"Blue Cross Blue Shield of Illinois . 90\u2010day supply program. Available at: www.bcbsil.com\/employer\/main_meds.htm.Accessed September 20 2018."},{"key":"e_1_3_2_18_2","unstructured":"Cigna . Cigna comprehensive drug list. Available at: www.cigna.com\/static\/docs\/medicare\u20102018\/formulary\u2010ea\u2010az.pdf.Accessed September 20 2018."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2017.23.3.337"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.016215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:00:09Z","timestamp":1715583609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.016215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,5]]}},"alternative-id":["10.1161\/JAHA.119.016215"],"URL":"https:\/\/doi.org\/10.1161\/jaha.119.016215","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e016215"}}