{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:31:58Z","timestamp":1753889518474,"version":"3.41.2"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,6,2]]},"abstract":"\n Background<\/jats:title>\n \n Continuing antiplatelet therapy (\n APT<\/jats:styled-content>\n ) has been generally recommended during noncardiac surgery, but it is uncertain if preoperative discontinuation of\n APT<\/jats:styled-content>\n has been avoided or harmful in patients with second\u2010generation drug\u2010eluting coronary stents.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients undergoing noncardiac surgery after second\u2010generation drug\u2010eluting coronary stent implantation were assessed in a multicenter cohort in Korea. Net adverse clinical events within 30\u00a0days postoperatively, defined as all\u2010cause death, major adverse cardiac events, and major bleeding, were evaluated. Of 3582 eligible patients, 49% patients discontinued\n APT<\/jats:styled-content>\n during noncardiac surgery. The incidence of net adverse clinical events was comparable between patients with continuation versus discontinuation (4.1% versus 3.4%;\n P<\/jats:italic>\n =0.257) of\n APT<\/jats:styled-content>\n during noncardiac surgery. Perioperative discontinuation of\n APT<\/jats:styled-content>\n did not impact on net adverse clinical events (adjusted hazard ratio [HR], 1.00; 95% CI, 0.69\u20131.44;\n P<\/jats:italic>\n =0.995). In subgroup analysis, patients undergoing intra\u2010abdominal surgery were exposed to less risk of major bleeding by discontinuing\n APT<\/jats:styled-content>\n (adjusted HR, 0.26; 95%\n CI<\/jats:styled-content>\n , 0.08\u20130.91;\n P<\/jats:italic>\n =0.035). Prolonged discontinuation of\n APT<\/jats:styled-content>\n for \u22659\u00a0days was associated with higher risk of a major adverse cardiac event compared with continuing\n APT<\/jats:styled-content>\n (adjusted HR, 3.38; 95%\n CI,<\/jats:styled-content>\n 1.36\u20138.38;\n P<\/jats:italic>\n =0.009).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n APT<\/jats:styled-content>\n was discontinued preoperatively in almost half of patients with second\u2010generation drug\u2010eluting coronary stents. Our explorative analysis showed that there was no significant impact of discontinuing\n APT<\/jats:styled-content>\n on the risk of perioperative adverse events except that discontinuing\n APT<\/jats:styled-content>\n may be associated with decreased hemorrhagic risk in patients undergoing intra\u2010abdominal surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n ; Unique identifier:\n NCT<\/jats:styled-content>\n 03908463.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.016218","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:09:38Z","timestamp":1589620178000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Patterns of Antiplatelet Therapy During Noncardiac Surgery in Patients With Second\u2010Generation Drug\u2010Eluting Stents"],"prefix":"10.1161","volume":"9","author":[{"given":"Choongki","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology Ewha Womans University College of Medicine Seoul Hospital Seoul Korea"},{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeongsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungsoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Dankook University Hospital Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oh\u2010Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yongin Severance Hospital Yonsei University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Kwan","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology National Health Insurance Service Ilsan Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ewha Womans University College of Medicine Seoul Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Youn","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHA Bundang Medical Center CHA University Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoyoun","family":"Won","sequence":"additional","affiliation":[{"name":"Cardiovascular & Arrhythmia Center Chung\u2010Ang University Hospital Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsung","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Myongji Hospital Hanyang University College of Medicine Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kangnam Sacred Heart Hospital Hallym University Medical Center Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Hyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology Myongji Hospital Hanyang University College of Medicine Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology National Health Insurance Service Ilsan Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung\u2010Kwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Gangnam Severance Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul 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