{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:59Z","timestamp":1787018099837,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"\n Background<\/jats:title>\n \n Bempedoic acid (\n BA<\/jats:styled-content>\n ) is a novel lipid\u2010lowering drug. We performed a systematic review and meta\u2010analysis on efficacy and safety of\n BA<\/jats:styled-content>\n compared with standard treatment in patients with hypercholesterolemia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Studies were systematically searched in the PubMed, Web of Science, Scopus, and\n EMBASE<\/jats:styled-content>\n databases. Efficacy outcome was represented by percentage changes (mean difference [\n MD<\/jats:styled-content>\n ] with pertinent 95%\n CIs<\/jats:styled-content>\n ) in total cholesterol, low\u2010density lipoprotein cholesterol, triglycerides, high\u2010density lipoprotein cholesterol, apolipoprotein B, non\u2013\n high\u2010density lipoprotein cholesterol<\/jats:styled-content>\n , and hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein) in\n BA<\/jats:styled-content>\n patients and controls. Seven studies were included (2767\n BA<\/jats:styled-content>\n \u2010treated patients and 1469 controls), showing a more significant reduction in\n low\u2010density lipoprotein cholesterol<\/jats:styled-content>\n (\n MD<\/jats:styled-content>\n , \u221217.5%; 95%\n CI<\/jats:styled-content>\n , \u221222.9% to \u221212.0%),\n total cholesterol<\/jats:styled-content>\n (\n MD<\/jats:styled-content>\n , \u221210.9%; 95%\n CI<\/jats:styled-content>\n , \u221213.3% to \u22128.5%), non\u2013\n high\u2010density lipoprotein cholesterol<\/jats:styled-content>\n (\n MD,<\/jats:styled-content>\n \u221212.3%; 95%\n CI<\/jats:styled-content>\n , \u221215.3% to \u22129.20%), apolipoprotein B (\n MD<\/jats:styled-content>\n , \u221210.6%; 95%\n CI<\/jats:styled-content>\n , \u221213.2% to \u22128.02%), and hs\u2010CRP (\n MD<\/jats:styled-content>\n , \u221213.2%; 95%\n CI<\/jats:styled-content>\n , \u221216.7% to \u22129.79%) in\n BA<\/jats:styled-content>\n \u2010treated patients compared with controls. Results were confirmed when separately analyzing studies on patients with high cardiovascular risk, studies on statin\u2010intolerant patients, and studies on patients with hypercholesterolemia on maximally tolerated lipid\u2010lowering therapy.\n BA<\/jats:styled-content>\n \u2010treated subjects reported a higher rate of treatment discontinuation caused by adverse effects, of gout flare, and of increase in uric acid compared with controls. On the other hand,\n BA<\/jats:styled-content>\n \u2010treated patients showed a lower incidence of new\u2010onset diabetes mellitus than controls.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n BA<\/jats:styled-content>\n is associated with a significant reduction in\n low\u2010density lipoprotein cholesterol<\/jats:styled-content>\n ,\n total cholesterol<\/jats:styled-content>\n , non\u2013\n high\u2010density lipoprotein cholesterol<\/jats:styled-content>\n , apolipoprotein B, and hs\u2010CRP compared with standard treatment. Documented efficacy is accompanied by an acceptable safety profile.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.119.016262","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T05:01:11Z","timestamp":1595307671000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1161","volume":"9","author":[{"given":"Alessandro","family":"Di Minno","sequence":"first","affiliation":[{"name":"Department of Pharmacy Federico II University Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Lupoli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology Federico II University Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Poggio","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Forte","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Spadarella","sequence":"additional","affiliation":[{"name":"Postgraduation School in Radiodiagnostics Universit\u00e0 Degli Studi di Milano Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Iannuzzo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Nicola Dario","family":"Di Minno","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13985"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e31827aad9e"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.03.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.08.651"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32290-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.02.024"},{"issue":"1484","key":"e_1_3_2_9_2","article-title":"Lipid\u2010lowering therapy and goal achievement in high\u2010risk patients from French general practice","volume":"40","author":"Ferrieres J","year":"2018","unstructured":"Ferrieres J, Gorcyca K, Iorga SR, Ansell D, Steen DL. 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