{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:32:54Z","timestamp":1775478774309,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Women with ischemia and no obstructive coronary artery disease are increasingly recognized and found to be at risk for major adverse cardiovascular events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 214 women with suspected ischemia and no obstructive coronary artery disease who completed baseline and 1\u2010year follow\u2010up vasodilatory stress cardiac magnetic resonance imaging, we investigated temporal trends in angina (Seattle Angina Questionnaire [SAQ]), myocardial perfusion reserve index, blood pressure, and left ventricular (LV) remodeling and function from baseline to 1\u2010year follow\u2010up and explored associations between these different parameters. We observed concordant positive trends in 4\/5 SAQ domains, SAQ\u20107, myocardial perfusion reserve index, blood pressure, LV mass, and LV mass\u2010to\u2010volume ratio. There was no association between SAQ\u20107 improvement and myocardial perfusion reserve index improvement over 1\u2010year follow\u2010up (\n              <jats:italic>P<\/jats:italic>\n              =0.1). Higher indexed LV end\u2010diastolic volume and time to peak filling rate at baseline were associated with increased odds of clinically relevant SAQ\u20107 improvement (odds ratio [OR], 1.05; 95% CI, 1.0\u20131.1; and OR, 2.40; 95% CI, 1.1\u20135.0, respectively). Hypertension was associated with decreased odds of SAQ\u20107 improvement (OR, 0.41; 95% CI, 0.19\u20130.91).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In women with ischemia and no obstructive coronary artery disease clinically treated with cardiac medications over 1 year, we observed concurrent temporal trends toward improvement in SAQ, myocardial perfusion reserve index, blood pressure, LV mass, and LV mass\u2010to volume ratio. We showed that abnormalities in LV morphology and diastolic function at baseline were predictive of clinically significant improvement in angina at follow\u2010up, whereas history of hypertension was associated with lower odds. Future studies are needed to assess the mechanisms and treatments responsible for the improvements we observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02582021.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.016305","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T09:16:38Z","timestamp":1592990198000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal Trends in Angina, Myocardial Perfusion, and Left Ventricular Remodeling in Women With No Obstructive Coronary Artery Disease Over 1\u2010Year Follow\u2010Up: Results From WISE\u2010CVD"],"prefix":"10.1161","volume":"9","author":[{"given":"Odayme","family":"Quesada","sequence":"first","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody","family":"Hermel","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nissi","family":"Suppogu","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haider","family":"Aldiwani","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrisandra","family":"Shufelt","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Emory Women\u2019s Heart Center Emory Clinical Cardiovascular Research Institute Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galen","family":"Cook\u2010Wiens","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Maughan","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women\u2019s Heart Center Cedars Sinai Smidt Heart Institute Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[{"name":"Taper Imaging Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise E. J.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Taper Imaging Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Handberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Florida Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Florida Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-5155","authenticated-orcid":false,"given":"C. 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