{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:47:55Z","timestamp":1790279275529,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,9,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Takotsubo syndrome (TS) is a potentially life\u2010threatening acute cardiac syndrome with a clinical presentation similar to myocardial infarction and for which the natural history, management, and outcome remain incompletely understood. Our aim was to assess the relative short\u2010term mortality risk of TS, ST\u2010segment\u2013elevation myocardial infarction (STEMI), and non\u2010STEMI (NSTEMI) and to identify predictors of in\u2010hospital complications and poor prognosis in patients with TS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is an observational cohort study based on the data from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). We included all patients (n=117\u00a0720) who underwent coronary angiography in Sweden attributed to TS (N=2898 [2.5%]), STEMI (N=48\u00a0493 [41.2%]), or NSTEMI (N=66\u00a0329 [56.3%]) between January 2009 and February 2018. We compared patients with TS to those with NSTEMI or STEMI. The primary end point was all\u2010cause mortality at 30\u00a0days. Secondary outcomes were acute heart failure (Killip Class \u22652) and cardiogenic shock (Killip Class 4) at the time of angiography. Patients with TS were more often women compared with patients with STEMI or NSTEMI. TS was associated with unadjusted and adjusted 30\u2010day mortality risks lower than STEMI (adjusted hazard ratio [adjHR], 0.60; 95% CI, 0.48\u20130.76;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but higher than NSTEMI (adjHR, 2.70; 95% CI, 2.14\u20133.41;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Compared with STEMI, TS was associated with a similar risk of acute heart failure (adjHR, 1.26; 95% CI, 0.91\u20131.76;\n              <jats:italic>P<\/jats:italic>\n              =0.16) but a lower risk of cardiogenic shock (adjHR, 0.55; 95% CI, 0.34\u20130.89;\n              <jats:italic>P<\/jats:italic>\n              =0.02). The relative 30\u2010day mortality risk for TS versus STEMI and NSTEMI was higher for smokers than nonsmokers (adjusted\n              <jats:italic>P<\/jats:italic>\n              interaction STEMI=0.01 and\n              <jats:italic>P<\/jats:italic>\n              interaction NSTEMI=0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The 30\u2010day mortality rate in TS was higher than in NSTEMI but lower than STEMI despite a similar risk of acute heart failure in TS and STEMI. Among patients with TS, smoking was an independent predictor of mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.017290","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T08:56:37Z","timestamp":1630486597000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Short\u2010 and Long\u2010Term Clinical Outcomes for Patients With Takotsubo Syndrome and Patients With Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-4451","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Redfors","sequence":"first","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg 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Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-345X","authenticated-orcid":false,"given":"Ole","family":"Frobert","sequence":"additional","affiliation":[{"name":"The Department of Cardiology Faculty of Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petur","family":"Petursson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-1338","authenticated-orcid":false,"given":"Per","family":"Tornvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institute Stockholm 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Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Lyon","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit Royal Brompton Hospital London United Kingdom"},{"name":"National Heart and Lung InstituteImperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-9736","authenticated-orcid":false,"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"The Department of Medical Sciences, Cardiology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-5766","authenticated-orcid":false,"given":"David","family":"Erlinge","sequence":"additional","affiliation":[{"name":"The Department of Cardiology Sk\u00e5ne University Hospital Lund 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