{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:26:47Z","timestamp":1788251207141,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It is unclear whether HIV infection affects the long\u2010term prognosis after an acute coronary syndrome (ACS). The objective of the current study was to compare rates of major adverse cardiac and cerebrovascular events after a first ACS between people living with HIV (PLHIV) and HIV\u2010uninfected (HIV\u2212) patients, and to identify determinants of cardiovascular prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consecutive PLHIV and matched HIV\u2212 patients with a first episode of ACS were enrolled in 23 coronary intensive care units in France. Patients were matched for age, sex, and ACS type. The primary end point was major adverse cardiac and cerebrovascular events (cardiac death, recurrent ACS, recurrent coronary revascularization, and stroke) at 36\u2010month follow\u2010up. A total of 103 PLHIV and 195 HIV\u2212 patients (mean age, 49 years [SD, 9 years]; 94.0% men) were included. After a mean of 36.6 months (SD, 6.1 months) of follow\u2010up, the risk of major adverse cardiac and cerebrovascular events was not statistically significant between PLHIV and HIV\u2212 patients (17.8% and 15.1%,\n              <jats:italic>P<\/jats:italic>\n              =0.22; multivariable hazard ratio [HR], 1.60; 95% CI, 0.67\u20133.82 [\n              <jats:italic>P<\/jats:italic>\n              =0.29]). Recurrence of ACS was more frequent among PLHIV (multivariable HR, 6.31; 95% CI, 1.32\u201330.21 [\n              <jats:italic>P<\/jats:italic>\n              =0.02]). Stratified multivariable Cox models showed that HIV infection was the only independent predictor for ACS recurrence. PLHIV were less likely to stop smoking (47% versus 75%;\n              <jats:italic>P<\/jats:italic>\n              =0.01) and had smaller total cholesterol decreases (\u201322.3 versus \u201335.0\u00a0mg\/dL;\n              <jats:italic>P<\/jats:italic>\n              =0.04).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Although the overall risk of major adverse cardiac and cerebrovascular events was not statistically significant between PLHIV and HIV\u2212 individuals, PLHIV had a higher rate of recurrent ACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT00139958.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.119.017578","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:16:29Z","timestamp":1598433389000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["HIV Infection and Long\u2010Term Residual Cardiovascular Risk After Acute Coronary Syndrome"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-9678","authenticated-orcid":false,"given":"Franck","family":"Boccara","sequence":"first","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"},{"name":"National Institute of Health and Medical Research INSERM UMR_S 938 Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Mary\u2010Krause","sequence":"additional","affiliation":[{"name":"INSERM Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Potard","sequence":"additional","affiliation":[{"name":"INSERM Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Teiger","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit Henri Mondor University Hospital Assistance Publique H\u00f4pitaux de Paris Cr\u00e9teil France"},{"name":"Inserm CIC 1430 et U955 Team 3 Henri Mondor University Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-8525","authenticated-orcid":false,"given":"Nadjib","family":"Hammoudi","sequence":"additional","affiliation":[{"name":"Inserm UMRS 1166 Institute of Cardiometabolism and Nutrition (ICAN) ACTION Study Group and Institute of Cardiology (AP\u2010HP) H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Chauvet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ederhy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Dufour\u2010Soulat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Ancedy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-5706","authenticated-orcid":false,"given":"Pascal","family":"Nhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroumadi","family":"Adavane","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine AP\u2010HP H\u00f4pitaux de l\u2019Est Parisien H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-2941","authenticated-orcid":false,"given":"Ph. 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