{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:07:32Z","timestamp":1791410852348,"version":"4.3.3"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Absolute hyperemic coronary blood flow and microvascular resistances can be measured by continuous thermodilution with a dedicated infusion catheter. We aimed to determine the mechanisms of this hyperemic response in animal.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Twenty open chest pigs were instrumented with flow probes on coronary arteries. The following possible mechanisms of saline\u2010induced hyperemia were explored compared with maximal hyperemia achieve with adenosine by testing: (1) various infusion rates; (2) various infusion content and temperature; (3) NO production inhibition with L\u2010arginine methyl ester and endothelial denudation; (4) effects of vibrations generated by rotational atherectomy and of infusion through one end\u2010hole versus side\u2010holes. Saline infusion rates of 5, 10 and 15\u00a0mL\/min did not reach maximal hyperemia as compared with adenosine. Percentage of coronary blood flow expressed in percent of the coronary blood flow after adenosine were 48\u00b117% at baseline, 57\u00b118% at 5\u00a0mL\/min, 65\u00b117% at 10\u00a0mL\/min, 82\u00b126% at 15\u00a0mL\/min and 107\u00b118% at 20\u00a0mL\/min. Maximal hyperemia was observed during infusion of both saline at body temperature and glucose 5%, after endothelial denudation,\n              <jats:sc>l\u2010<\/jats:sc>\n              arginine methyl ester administration, and after stent implantation. The activation of a Rota burr in the first millimeters of the epicardial artery also induced maximal hyperemia. Maximal hyperemia was achieved by infusion through lateral side\u2010holes but not through an end\u2010hole catheter.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Infusion of saline at 20\u00a0mL\/min through a catheter with side holes in the first millimeters of the epicardial artery induces maximal hyperemia. The data indicate that this vasodilation is related neither to the composition\/temperature of the indicator nor is it endothelial mediated. It is suggested that it could be elicited by epicardial wall vibrations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.015793","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T09:03:02Z","timestamp":1595322182000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Intracoronary Saline\u2010Induced Hyperemia During Coronary Thermodilution Measurements of Absolute Coronary Blood Flow: An Animal Mechanistic Study"],"prefix":"10.1161","volume":"9","author":[{"given":"Julien","family":"Adjedj","sequence":"first","affiliation":[{"name":"Department of Cardiology Institut Arnault Tzanck Saint Laurent du Var France"},{"name":"Department of Cardiology Lausanne University Center Hospital Lausanne Switzerland"},{"name":"U955\u2010IMRB Equipe 03 Inserm UPEC Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort Maisons\u2010Alfort France"},{"name":"Universit\u00e9 Paris Est UMR_S955 UPEC Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort Cr\u00e9teil France"},{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Picard","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes Universit\u00e9 Paris Descartes Paris France"},{"name":"AP\u2010HP, H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Collet","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"UMR 970 Inserm Paris Cardiovascular Research Center H\u00f4pital Europ\u00e9en Georges Pompidou Paris 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