{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:25:28Z","timestamp":1781717128316,"version":"3.54.5"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"\n Background<\/jats:title>\n \n The incidence of conduction abnormalities requiring permanent pacemaker implantation (\n PPI<\/jats:styled-content>\n ) after transcatheter aortic valve replacement (\n TAVR<\/jats:styled-content>\n ) with early and later generation prostheses remains debated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Based on the administrative hospital\u2010discharge database, we collected information for all patients treated with\n TAVR<\/jats:styled-content>\n between 2010 and 2019 in France. We compared the incidence of\n PPI<\/jats:styled-content>\n after\n TAVR<\/jats:styled-content>\n according to the type and generation of valve implanted. A total of 49\u00a0201 patients with aortic stenosis treated with\n TAVR<\/jats:styled-content>\n using the balloon\u2010expandable (\n BE<\/jats:styled-content>\n ) Edwards\n SAPIEN<\/jats:styled-content>\n valve (early Sapien\n XT<\/jats:styled-content>\n and latest Sapien 3) or the self\u2010expanding (\n SE<\/jats:styled-content>\n ) Medtronic CoreValve (early CoreValve and latest Evolut R) were found in the database. Mean (\n SD<\/jats:styled-content>\n ) follow\u2010up was 1.2 (1.5\u00a0years) (median [interquartile range] 0.6 [0.1\u20132.0] years).\n PPI<\/jats:styled-content>\n after the procedure was reported in 13\u00a0289 patients, among whom 11\u00a0010 (22.4%) had implantation during the first 30\u00a0days. In multivariable analysis, using early\n BE TAVR<\/jats:styled-content>\n as reference, adjusted odds ratio (95%\n CI<\/jats:styled-content>\n ) for\n PPI<\/jats:styled-content>\n during the first 30\u00a0days was 0.88 (0.81\u20130.95) for latest\n BE TAVR<\/jats:styled-content>\n , 1.40 (1.27\u20131.55) for early\n SE TAVR<\/jats:styled-content>\n , and 1.17 (1.07\u20131.27) for latest\n SE TAVR<\/jats:styled-content>\n . Compared with early\n BE TAVR<\/jats:styled-content>\n , the adjusted hazard ratio for\n PPI<\/jats:styled-content>\n during the whole follow\u2010up was 1.01 (0.95\u20131.08) for latest\n BE TAVR<\/jats:styled-content>\n , 1.30 (1.21\u20131.40) for early\n SE TAVR<\/jats:styled-content>\n , and 1.25 (1.18\u20131.34) for latest\n SE TAVR<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with aortic stenosis treated with\n TAVR<\/jats:styled-content>\n , our systematic analysis at a nationwide level found higher rates of\n PPI<\/jats:styled-content>\n than previously reported.\n BE<\/jats:styled-content>\n technology was independently associated with lower incidence rates of\n PPI<\/jats:styled-content>\n both at the acute and chronic phases than\n SE<\/jats:styled-content>\n technology. Recent generations of\n TAVR<\/jats:styled-content>\n were not independently associated with different rates of\n PPI<\/jats:styled-content>\n than early generations during the overall follow\u2010up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.120.015896","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T09:00:21Z","timestamp":1588410021000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Pacemaker Implantation After Balloon\u2010 or Self\u2010Expandable Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis"],"prefix":"10.1161","volume":"9","author":[{"given":"Arnaud","family":"Bisson","sequence":"first","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bodin","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Herbert","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"},{"name":"Service d\u2019information M\u00e9dicale, d\u2019\u00e9pid\u00e9miologie et d\u2019\u00e9conomie de la sant\u00e9 Centre Hospitalier Universitaire et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Lacour","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Saint Etienne","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Pierre","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Clementy","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Deharo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie Centre Hospitalier Universitaire Timone Marseille France"},{"name":"Inserm Inra C2VN Marseille France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Aix\u2010Marseille Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Babuty","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-1658","authenticated-orcid":false,"given":"Laurent","family":"Fauchier","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine EA7505 Universit\u00e9 de Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.079"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043971"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.017"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.11.020"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy805"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.12.023"},{"key":"e_1_3_1_10_2","unstructured":"Thiele H. A 2x2 randomized trial of self\u2010expandable vs balloon\u2010expandable valves and general vs local anesthesia in patients undergoing transcatheter aortic valve implantation. Presented at tct 23 September San Diego CA; 2018."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.053"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043785"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011206"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.022"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27230"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.068"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.07.015"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.07.026"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.014"}],"updated-by":[{"DOI":"10.1161\/jaha.119.014562","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000}}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.015896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:09:09Z","timestamp":1715598549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.015896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,5,5]]}},"alternative-id":["10.1161\/JAHA.120.015896"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.015896","relation":{"correction":[{"id-type":"doi","id":"10.1161\/JAHA.119.014562","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"assertion":[{"value":"2020-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e015896"}}