{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:47Z","timestamp":1792156967557,"version":"4.4.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p xml:lang=\"en\">The mechanisms underlying the effect of preconditioning on remote microvasculature remains undisclosed. The primary objective was to document the remote effect of ischemic preconditioning on microvascular function in humans. The secondary objective was to test if exercise also induces remote microvascular effects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 12 healthy young men and women participated in 2 experimental days in a random counterbalanced order. On one\u00a0day the participants underwent 4\u00d75\u00a0minutes of forearm ischemic preconditioning, and on the other day they completed 4\u00d75\u00a0minutes of hand\u2010grip exercise. On both days, catheters were placed in the brachial and femoral artery and vein for infusion of acetylcholine, sodium nitroprusside, and epoprostenol. Vascular conductance was calculated from blood flow measurements with ultrasound Doppler and arterial and venous blood pressures. Ischemic preconditioning enhanced (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) the remote vasodilator response to intra\u2010arterial acetylcholine in the leg at 5 and 90\u00a0minutes after application. The enhanced response was associated with a 6\u2010fold increase (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) in femoral venous plasma prostacyclin levels and with a transient increase (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) in arterial plasma levels of brain\u2010derived neurotrophic factor and vascular endothelial growth factor. In contrast, hand\u2010grip exercise did not influence remote microvascular function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p xml:lang=\"en\">These findings demonstrate that ischemic preconditioning of the forearm improves remote microvascular endothelial function and suggest that one of the underlying mechanisms is a humoral\u2010mediated potentiation of prostacyclin formation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016017","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T09:09:36Z","timestamp":1596013776000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Ischemic Preconditioning Improves Microvascular Endothelial Function in Remote Vasculature by Enhanced Prostacyclin 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Sports University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United Kingdom"},{"name":"Department of Physiology Radboud Institute for Health Sciences Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-2523","authenticated-orcid":false,"given":"Lasse","family":"Gliemann","sequence":"additional","affiliation":[{"name":"Section of Integrative Physiology Department of Nutrition, Exercise and Sports University of Copenhagen 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