{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:32:43Z","timestamp":1793968363420,"version":"4.8.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Following cryptogenic stroke, guidelines recommend cardiac monitoring for occult atrial fibrillation (AF). We aimed to evaluate predictors of AF during long\u2010term implantable cardiac monitoring.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 293 consecutive patients who underwent implantable cardiac monitor implant (Medtronic LINQ) following hospitalization for cryptogenic stroke at the University of Rochester Medical Center from January 2013 to September 2018. Multivariable Cox proportional hazards regression modeling was used to identify predictors of AF during long\u2010term monitoring. At 36\u00a0months of follow\u2010up, the cumulative rate of implantable cardiac monitor\u2013detected AF events was 32% in the total study population. Multivariable analysis identified age \u226570\u00a0years as the most powerful predictor of the development of AF events during follow\u2010up (hazard ratio, 2.28 [95% CI, 1.39\u20133.76];\n              <jats:italic>P<\/jats:italic>\n              =0.001). Replacing age with the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc (congestive heart failure, hypertension, age, diabetes mellitus, stroke, vascular disease, age, sex category) score resulted in a weaker association, for which each 1\u2010point increment in the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASC score was associated with an 18% increased risk of developing AF (95% CI, 1.00\u20131.38;\n              <jats:italic>P<\/jats:italic>\n              =0.047). Consistent results were shown using Kaplan\u2013Meier analysis by age and by the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              VASc score.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Cryptogenic stroke patients continue to develop AF episodes during 36\u00a0months of implantable cardiac monitoring following the index event. Age is the most powerful predictor of occult AF in this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016040","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T09:02:33Z","timestamp":1595322153000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Predictors of Atrial Fibrillation During Long\u2010Term Implantable Cardiac Monitoring Following Cryptogenic Stroke"],"prefix":"10.1161","volume":"9","author":[{"given":"Michael","family":"Riordan","sequence":"first","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Opaskar","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Yoruk","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa","family":"Younis","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogachan","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Rosero","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9384","authenticated-orcid":false,"given":"Mehmet K.","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology Clinical Cardiovascular Research Center University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx731"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318284056a"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.026"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028845"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.3180"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.06.039"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.016040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:01:43Z","timestamp":1715598103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.016040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":11,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8,4]]}},"alternative-id":["10.1161\/JAHA.120.016040"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.016040","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"assertion":[{"value":"2020-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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