{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:04:29Z","timestamp":1792728269057,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with persistent atrial fibrillation (AF) undergoing catheter\u2010based AF ablation have lower success rates than those with paroxysmal AF. We compared healthcare use and clinical outcomes between patients according to their AF subtypes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Consecutive patients undergoing AF ablation were prospectively identified from a population\u2010based registry in Ontario, Canada. Via linkage with administrative databases, we performed a retrospective analysis comparing the following outcomes between patients with persistent and paroxysmal AF: healthcare use (defined as AF\u2010related hospitalizations\/emergency room visits), periprocedural complications, and mortality. Multivariable Poisson modeling was performed to compare the rates of AF\u2010related and all\u2010cause hospitalizations\/emergency room visits in the year before versus after ablation. Between April 2012 and March 2016, there were 3768 consecutive patients who underwent first\u2010time AF ablation, of whom 1040 (27.6%) had persistent AF. The mean follow\u2010up was 1329\u00a0days. Patients with persistent AF had higher risk of AF\u2010related hospitalization\/emergency room visits (hazard ratio [HR], 1.21; 95% CI, 1.09\u20131.34), mortality (HR, 1.74; 95% CI, 1.15\u20132.63), and periprocedural complications (odds ratio, 1.36; 95% CI, 1.02\u20131.75) than those with paroxysmal AF. In the overall cohort, there was a 48% reduction in the rate of AF\u2010related hospitalization\/emergency room visits in the year after versus before ablation (rate ratio [RR], 0.52; 95% CI, 0.48\u20130.56). This reduction was observed for patients with paroxysmal (RR, 0.45; 95% CI, 0.41\u20130.50) and persistent (RR, 0.74; 95% CI, 0.63\u20130.87) AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Although patients with persistent AF had higher risk of adverse outcomes than those with paroxysmal AF, ablation was associated with a favorable reduction in downstream AF\u2010related healthcare use, irrespective of AF type.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016071","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T10:25:00Z","timestamp":1609410300000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Differences in Healthcare Use Between Patients With Persistent and Paroxysmal Atrial Fibrillation Undergoing Catheter\u2010Based Atrial Fibrillation Ablation: A Population\u2010Based Cohort Study From Ontario, Canada"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-7313","authenticated-orcid":false,"given":"Andrew C. T.","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto Ontario Canada"},{"name":"Peter Munk Cardiac CentreToronto General HospitalUniversity Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-1080","authenticated-orcid":false,"given":"Harindra C.","family":"Wijeysundera","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Ontario Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto Ontario Canada"},{"name":"ICES Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[{"name":"ICES Toronto Ontario 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H.","family":"Birnie","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1723-6154","authenticated-orcid":false,"given":"Eugene","family":"Crystal","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Ontario Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Ha","sequence":"additional","affiliation":[{"name":"Trillium Health Partners Mississauga Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7580","authenticated-orcid":false,"given":"Jeff S.","family":"Healey","sequence":"additional","affiliation":[{"name":"Department of Medicine Hamilton Health Sciences Population Health Research Institute McMaster University Hamilton 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