{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:23:24Z","timestamp":1783016604611,"version":"3.54.6"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long\u2010term sequelae. However, the temporal trends, predictors, and outcomes of stroke in women with HDP at delivery remain unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">All HDP delivery hospitalizations with or without stroke event (ischemic, hemorrhagic, or unspecified) between 2004 and 2014 in the United States National Inpatient Sample were analyzed to examine incidence, predictors, and prognostic impact of stroke. Of 4\u00a0240\u00a0284 HDP delivery hospitalizations, 3391 (0.08%) women had stroke. While the prevalence of HDP increased over time, incident stroke rates decreased from 10 to 6 per 10\u00a0000 HDP delivery hospitalizations between 2004 and 2014. Women with stroke were increasingly multimorbid, with some risk factors being more strongly associated with ischemic strokes, including congenital heart disease, peripheral vascular disease, dyslipidemia, and sickle cell disease. Delivery complications were also associated with stroke, including cesarean section (odds ratio [OR], 1.58; 95% CI, 1.33\u20131.86), postpartum hemorrhage (OR, 1.91; 95% CI, 1.33\u20131.86), and maternal mortality (OR, 99.78; 95% CI, 59.15\u2013168.31), independently of potential confounders. Women with stroke had longer hospital stays (median, 6 versus 3\u00a0days), higher hospital charges (median, $14\u00a0655 versus $4762), and a higher proportion of nonroutine discharge locations (38% versus 4%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The incidence of stroke in women with HDP has declined over time. While a relatively rare event, identification of women at highest risk of ischemic or hemorrhagic stroke on admission for delivery is important to reduce long\u2010term sequelae.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016182","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T09:10:37Z","timestamp":1596013837000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Temporal Trends in Pregnancy\u2010Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy"],"prefix":"10.1161","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-5636","authenticated-orcid":false,"given":"Pens\u00e9e","family":"Wu","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Research Group School of Primary, Community and Social Care Keele University Staffordshire United Kingdom"},{"name":"Academic Unit of Obstetrics and Gynaecology University Hospital of North Midlands Stoke\u2010on\u2010Trent United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-5335","authenticated-orcid":false,"given":"Kelvin P.","family":"Jordan","sequence":"additional","affiliation":[{"name":"School of Primary, Community and Social Care Keele University Staffordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-9981","authenticated-orcid":false,"given":"Carolyn A.","family":"Chew\u2010Graham","sequence":"additional","affiliation":[{"name":"School of Primary, Community and Social Care Keele University Staffordshire United Kingdom"},{"name":"National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West Midlands Keele University Staffordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Division of Cardiac Prevention and Rehabilitation Division of Cardiology University of Ottawa Heart Institute Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-7094","authenticated-orcid":false,"given":"Gina P.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology Emory University School of Medicine Atlanta GA"},{"name":"Emory Women\u2019s Heart Center Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9943-3484","authenticated-orcid":false,"given":"Ki E.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Florida College of Medicine Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-3379","authenticated-orcid":false,"given":"Lucy C.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Academic Centre King\u2019s College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-6158","authenticated-orcid":false,"given":"Phyo K.","family":"Myint","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences University of Aberdeen United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-9926","authenticated-orcid":false,"given":"Angela H. 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