{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:11:54Z","timestamp":1792671114194,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Splanchnic venous pooling induced by upright posture triggers a compensatory increase in heart rate (\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              ), a response that is exaggerated in patients with postural tachycardia syndrome. To assess whether abdominal compression attenuates orthostatic tachycardia and improves symptoms, 18 postural tachycardia syndrome patients (32\u00b12\u00a0years) were randomized to receive either abdominal compression (40\u00a0mm\u00a0Hg applied with an inflatable binder \u22482\u00a0minutes before standing) or propranolol (20\u00a0mg) in a placebo\u2010controlled, crossover study.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Systolic blood pressure,\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              , and symptoms were assessed while seated and standing, before and 2\u00a0hours postdrug. As expected, propranolol decreased standing\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              compared with placebo (81\u00b12 versus 98\u00b14\u00a0beats per minute;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and was associated with lower standing systolic blood pressure (93\u00b12 versus 100\u00b12\u00a0mm\u00a0Hg for placebo;\n              <jats:italic>P<\/jats:italic>\n              =0.002). Compression had no effect on standing\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              (96\u00b14\u00a0beats per minute) but increased standing systolic blood pressure compared with placebo and propranolol (106\u00b12\u00a0mm\u00a0Hg;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Neither propranolol nor compression improved symptoms compared with placebo. In 16 patients we compared the combination of abdominal compression and propranolol with propranolol alone. The combination had no additional effect on standing\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              (81\u00b12\u00a0beats per minute for both interventions) but prevented the decrease in standing systolic blood pressure produced by propranolol (98\u00b12 versus 93\u00b12\u00a0mm\u00a0Hg for propranolol;\n              <jats:italic>P<\/jats:italic>\n              =0.029), and significantly improved total symptom burden (\u22126\u00b12 versus \u22121\u00b12 for propranolol;\n              <jats:italic>P<\/jats:italic>\n              =0.041).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Splanchnic venous compression alone did not improve\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              or symptoms but prevented the blood pressure decrease produced by propranolol. The combination was more effective in improving symptoms than either alone. Splanchnic venous compression can be a useful adjuvant therapy to propranolol in postural tachycardia syndrome.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clini\u200bcaltr\u200bials.gov<\/jats:ext-link>\n              ; Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              00262470.\n            <\/jats:p>\n          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