{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:55Z","timestamp":1793831275228,"version":"4.6.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2020,5,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The role of drug\u2010coated balloons (DCBs) in the treatment of de novo coronary lesions is not well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Electronic databases and major conference proceedings were searched for randomized controlled trials that compared DCBs with stents or angioplasty for de novo coronary lesions. The primary outcome was target lesion revascularization. Summary estimates were conducted using random\u2010effects analysis complemented by several subgroup and sensitivity analyses. A total of 14 randomized controlled trials with 2483 patients were included. At a mean follow up of 12\u00a0months, DCBs were associated with no difference in the incidence of target lesion revascularization as compared with alternative strategies (risk ratio [RR], 0.79; 95% CI, 0.35\u20131.76). There was no difference in treatment effect based on the indication (ie, small\u2010vessel disease, myocardial infarction, bifurcation, or high bleeding risk) (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.22). DCBs were associated with lower target lesion revascularization compared with bare metal stents and similar target lesion revascularization compared with drug\u2010eluting stents (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.03). There was no difference between DCBs and control in terms of major adverse cardiac events, vessel thrombosis, or cardiovascular mortality. However, DCBs were associated with a lower incidence of myocardial infarction (RR, 0.48; 95% CI, 0.25\u20130.90) and all\u2010cause mortality (RR, 0.45; 95% CI, 0.22\u20130.94).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with de novo coronary lesions, use of DCBs was associated with comparable clinical outcomes irrespective of the indication or comparator device. DCBs had a similar rate of target lesion revascularization compared with drug\u2010eluting stents. A randomized trial powered for clinical outcomes and evaluating the role of DCBs for all\u2010comers is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.120.016224","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T05:13:22Z","timestamp":1589519602000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Clinical and Angiographic Outcomes With Drug\u2010Coated Balloons for De Novo Coronary Lesions: A Meta\u2010Analysis of Randomized Clinical Trials"],"prefix":"10.1161","volume":"9","author":[{"given":"Islam Y.","family":"Elgendy","sequence":"first","affiliation":[{"name":"Division of Cardiology Massachusetts General Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Medicine Cleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Florida Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed N.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitario de La Princesa IIS\u2010IP CIBER\u2010CV Universidad Aut\u00f3noma de Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivero","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitario de La Princesa IIS\u2010IP CIBER\u2010CV Universidad Aut\u00f3noma de Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitario de La Princesa IIS\u2010IP CIBER\u2010CV Universidad Aut\u00f3noma de Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001790"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005286"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0609-7"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz594"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.01.004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.08.010"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60657-2"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.09.009"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31719-7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31126-2"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00723"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.016"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(85)80003-7"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.195057"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1187"},{"key":"e_1_3_1_25_2","unstructured":"Cortese B. Drug\u2010coated balloon vs. drug\u2010eluting stent for small coronary vessel disease: 6\u00a0months primary outcome of the PICCOLETO II randomized clinical trial. Presented at the Transcatheter Cardiovascular Therapeutic meeting San Francisco CA September 2019."},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1126-x"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.020"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.04.008"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.07.005"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000755"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0957-6"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I1A10"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.156"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV14I10A191"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041099"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz698."},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.013"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27996"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015622"},{"key":"e_1_3_1_41_2","first-page":"393","article-title":"Outcomes with drug\u2010coated balloons for treating the side branch of coronary bifurcation lesions","volume":"30","author":"Megaly M","year":"2018","unstructured":"Megaly M, Rofael M, Saad M, Shishehbor M, Brilakis ES. Outcomes with drug\u2010coated balloons for treating the side branch of coronary bifurcation lesions. J Invasive Cardiol. 2018;30:393\u2013399.","journal-title":"J Invasive Cardiol"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.120.016224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:59:07Z","timestamp":1715587147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.120.016224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,18]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,5,18]]}},"alternative-id":["10.1161\/JAHA.120.016224"],"URL":"https:\/\/doi.org\/10.1161\/jaha.120.016224","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,18]]},"assertion":[{"value":"2019-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e016224"}}