{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:41:30Z","timestamp":1791308490922,"version":"4.3.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prognostic value of echocardiographic evaluation of right ventricular (RV) function in patients undergoing left\u2010sided valvular surgery has not been well described. The objective of this study is to determine the role of broad echocardiographic assessment of RV function in predicting short\u2010term outcomes after valvular surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Preoperative echocardiographic data, perioperative adverse outcomes, and 30\u2010day mortality were analyzed in patients who underwent left\u2010sided valvular surgery from 2006 to 2014. Echocardiographic parameters used to evaluate RV function include RV fractional area change, tricuspid annular plane systolic excursion, systolic movement of the RV lateral wall using tissue Doppler imaging (S'), RV myocardial performance index, and RV dP\/dt. Subjects with at least 3 abnormal parameters out of the 5 aforementioned indices were defined as having significant RV dysfunction. The study included 269 patients with valvular surgery (average age: 67\u00b115, 60.6% male, 148 aortic, and 121 mitral). RV dysfunction was found in 53 (19.7%) patients; 30\u2010day mortality occurred in 20 patients (7.5%). Compared with normal RV function, patients with RV dysfunction had higher 30\u2010day mortality (22.6% versus 3.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.01) and were at risk for developing multisystem failure\/shock (13.2% versus 3.2%;\n              <jats:italic>P<\/jats:italic>\n              =0.01). Multivariate analyses showed that preexisting RV dysfunction was the strongest predictor of increased 30\u2010day mortality (odds ratio: 3.5; 95% CI, 1.1\u201311.1;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Preoperative RV dysfunction identified by comprehensive echocardiographic assessment is a strong predictor of adverse outcomes following left\u2010sided valvular surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.120.016283","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T11:38:56Z","timestamp":1612870736000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Right Ventricular Dysfunction and Short\u2010Term Outcomes Following Left\u2010Sided Valvular Surgery: An Echocardiographic Study"],"prefix":"10.1161","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-1133","authenticated-orcid":false,"given":"Arooge","family":"Towheed","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-7671","authenticated-orcid":false,"given":"Rajesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Assiri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-3854","authenticated-orcid":false,"given":"George V.","family":"Moukarbel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadik A.","family":"Khuder","sequence":"additional","affiliation":[{"name":"Department of Medicine and Public Health University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Schwann","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Toledo Medical Center OH"},{"name":"Division of Cardiothoracic Surgery University of Massachusetts\u2010Baystate Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Bonnell","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Toledo Medical Center OH"},{"name":"Division of Cardiothoracic Surgery Parkridge Medical Center Chattanooga TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3925-5177","authenticated-orcid":false,"given":"Samer","family":"Khouri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(92)90008-U"},{"key":"e_1_3_1_3_2","first-page":"27","article-title":"[Pre\u2010 and postoperative right cardiac insufficiency in patients with mitral or mitral\u2010aortic valve diseases]","volume":"86","author":"Pinzani A","year":"1993","unstructured":"Pinzani A, de Gevigney G, Pinzani V, Ninet J, Milon H, Delahaye JP [Pre\u2010 and postoperative right cardiac insufficiency in patients with mitral or mitral\u2010aortic valve diseases]. 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