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Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia\/reperfusion injury. In this review, we discuss the pathophysiology and epigenetic modulations of ischemia\/reperfusion injury and focus on the neuroprotective and cardioprotective effects of\n            <jats:styled-content style=\"fixed-case\">histone deacetylase inhibitors<\/jats:styled-content>\n            . We also summarize the protective effects of\n            <jats:styled-content style=\"fixed-case\">histone deacetylase inhibitors<\/jats:styled-content>\n            for other vital organs and highlight the key research priorities for their successful translation to the bedside.\n          <\/jats:p>","DOI":"10.1161\/jaha.120.016349","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:42:58Z","timestamp":1590140578000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Histone Deacetylase Inhibitors: A Novel Strategy for Neuroprotection and Cardioprotection Following Ischemia\/Reperfusion Injury"],"prefix":"10.1161","volume":"9","author":[{"given":"Zachary","family":"Pickell","sequence":"first","affiliation":[{"name":"College of Literature Science and the Arts University of Michigan Ann Arbor MI"},{"name":"Department of Emergency Medicine Michigan Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery Michigan Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan B.","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Surgery Michigan Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-6969","authenticated-orcid":false,"given":"Cindy H.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Michigan Medicine University of Michigan Ann Arbor MI"},{"name":"Department of Surgery Michigan Medicine University of Michigan Ann Arbor MI"},{"name":"Michigan Center for Integrative Research in Critical Care University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1014"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(00)82028-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_2_6_2","first-page":"66","article-title":"Free radical\u2010mediated reperfusion injury: a selective review","volume":"8","author":"Bulkley GB","year":"1987","unstructured":"Bulkley GB. 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